Evidence map›Paper›PMID 39889339›Full record

ArticleBiomaterials2025

Self-healing and cell-free vascular grafts.

Yulun Wu, Mohamed Alaa Mohamed, Tai Yi, Arundhati Das, Clayton L Rumsey, Martin Trebbin, Christopher K Breuer, Stelios T Andreadis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yulun WuDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Mohamed Alaa MohamedDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Tai YiNationwide Children's Hospital, Columbus, OH, 43215, USA.
Arundhati DasDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Clayton L RumseyDepartment of Chemistry, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Martin TrebbinDepartment of Chemistry, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Christopher K BreuerNationwide Children's Hospital, Columbus, OH, 43215, USA.
Stelios T AndreadisDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, 14263, USA; Center of Cell, Gene and Tissue Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. Electronic address: sandread@buffalo.edu.

Funding

Cell-free vascular grafts: immunological response and vascular regenerationR01HL151196 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ANDREADIS, STELIOS THEOHARIS · 2020 to 2023
$2.4M
NHLBI NIH HHS R01 HL151196
6 · The paper itself

Abstract

We developed an innovative self-healing tissue engineering vessel (SH-TEV) that heals fast after repeated needle punctures, while maintaining artery like mechanical strength and toughness even under wet conditions. The SH-TEV is designed as a bilayer tube engineered by electrospinning an autonomous self-healing polyurethane, PU-DAA, around a tube of a native biomaterial, small intestinal submucosa (SIS), that can be functionalized with biomolecules to recruit host cells and promote endothelialization. The self-healing PU-DAA was designed to incorporate multi-strength H-bonds and reversible hydrazone bonds and exhibited high strength (3.95 ± 0.16 MPa), toughness (23.01 ± 2.37 MJ/m

Indexed as

Blood Vessel ProsthesisTissue EngineeringWound HealingAnimalsAortaBiocompatible MaterialsFibroblastsHumansMaleMaterials TestingPolyurethanesRatsRats, Sprague-DawleyBiocompatible MaterialsPolyurethanes

Identifiers

PMID39889339
PMCPMC13593358

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.