Evidence map›Paper›PMID 39889768›Full record

ReviewNeoReviews2025

Applications of Metabolomics and Lipidomics in the Neonatal Intensive Care Unit.

Jonathan D Reiss, Samson J Mataraso, Lindsay F Holzapfel, Ivana Marić, Maya M Kasowski, Camilia R Martin, Jonathan Z Long, David K Stevenson, Gary M Shaw, Stanford Metabolic Health Center

Abstract readReview
In one paragraph

Review in NeoReviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Artificial intelligence-guided nutritional therapy in the ICU.Current opinion in clinical nutrition and metabolic care · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Metabolomics in neonatal sepsis: A critical appraisal of current evidence.Computational and structural biotechnology journal · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan D ReissDepartment of Pediatrics, Division of Neonatology, Stanford University School of Medicine, Palo Alto, California.
Samson J MatarasoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California.
Lindsay F HolzapfelDepartment of Pediatrics, Division of Neonatology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas.
Ivana MarićDepartment of Pediatrics, Division of Neonatology, Stanford University School of Medicine, Palo Alto, California.
Maya M KasowskiMetabolic Health Center, Stanford University, Palo Alto, California.
Camilia R MartinDivision of Neonatology, Department of Pediatrics, Weill Cornell Medicine, New York, New York.
Jonathan Z LongDepartment of Pathology, Chemistry, Engineering and Medicine for Human Health, Stanford University School of Medicine, Stanford, California.
David K StevensonDepartment of Pediatrics, Division of Neonatology, Stanford University School of Medicine, Palo Alto, California.
Gary M ShawDepartment of Pediatrics, Division of Neonatology, Stanford University School of Medicine, Palo Alto, California.
Stanford Metabolic Health Center

Funding

NICHD NIH HHS L40 HD109887
6 · The paper itself

Abstract

The metabolome and lipidome comprise the thousands of molecular compounds in an organism. Molecular compounds consist of the upstream metabolic components of intracellular reactions or the byproducts of cellular pathways. Molecular and biochemical perturbations are associated with disorders in newborns and infants. The diagnosis of inborn errors of metabolism has relied on targeted metabolomics for several decades. Newer approaches offer the potential to identify novel biomarkers for common diseases of the newborn and infant. They may also elucidate novel predictive or diagnostic measures for a variety of health trajectories. Here, we review the relevance of the metabolome and lipidome for common disorders and highlight challenges and opportunities for future investigations.

Indexed as

Intensive Care Units, NeonatalLipidomicsMetabolism, Inborn ErrorsMetabolomicsBiomarkersHumansInfant, NewbornBiomarkers

Identifiers

PMID39889768
PMCPMC12079657

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.