Evidence map›Paper›PMID 39890135›Full record

ArticleBMJ open2025

Protocol for a randomised 'screen-and-treat'

Sergio George, Yalda Lucero, Camila Cabrera, Beatriz Zabala Torres, Lilian Fernández, Nora Mamani, Anne Lagomarcino, Ximena Aguilera, Miguel O'Ryan

Erratum issued Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05926804 (A Randomized "Screen and Treat" Helicobacter Pylori Eradication Trial in 14-18 Years Old Adolescents Residing in Three Regions of Chile), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05926804 narecruitingnot on this map

A Randomized "Screen and Treat" Helicobacter Pylori Eradication Trial in 14-18 Years Old Adolescents Residing in Three Regions of Chile: Effectiveness and Microbiological-host Implications

TypeinterventionalSponsorMiguel O'Ryan GallardoRan2022 to 2027Enrolled500ConditionsHelicobacter Pylori InfectionArmsLansoprazole, Amoxicillin, Clarithromycin, Metronidazole
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pathogenicity ofWorld journal of clinical oncology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sergio GeorgeDepartment of Pediatrics and Pediatric Surgery (Eastern Campus), Luis Calvo Mackenna Hospital, Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0002-1034-1373
Yalda LuceroDepartment of Pediatrics and Pediatric Surgery (Northern Campus), Dr. Roberto del Río Hospital, Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile.
Camila CabreraMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile.
Beatriz Zabala TorresCampus Lillo, Universidad de Aysén, Coyhaique, Chile.
Lilian FernándezDepartment of Pediatrics and Pediatric Surgery, Universidad de La Frontera, Temuco, Araucania Region, Chile.
Nora MamaniMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile.
Anne LagomarcinoMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile.
Ximena AguileraMonroe Carrell Children's Hospital, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Miguel O'RyanMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile moryan@uchile.cl.ORCID http://orcid.org/0000-0002-7926-2163

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGastric cancer is a major global health concern, being the final stage of a long-term process, primarily associated with METHODS AND ANALYSIS: The screening phase will involve testing 500-1000 asymptomatic adolescents aged 14-18 from three cities in Chile using the urea breath test (UBT) to identify 210 participants with persistent infection. They will proceed to a randomised, non-blinded, controlled trial, receiving either a sequential eradication scheme for ETHICS AND DISSEMINATION: Approved by the Human Research Ethics Committee at the Faculty of Medicine, University of Chile (073-2022). Findings will be disseminated in peer-reviewed journals and scientific meetings to guide future practices. TRIAL REGISTRATION NUMBER: NCT05926804.

Indexed as

Anti-Bacterial AgentsHelicobacter InfectionsHelicobacter pyloriAdolescentBreath TestsChileFecesFemaleGastrointestinal MicrobiomeHumansMaleMass ScreeningRandomized Controlled Trials as TopicAnti-Bacterial AgentsAdolescentsClinical TrialPaediatric infectious disease and immunisation

Identifiers

PMID39890135
PMCPMC11784427

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.