Evidence map›Paper›PMID 39890641›Full record

ArticleSkeletal radiology2025

Statin use and longitudinal bone marrow lesion burden: analysis of knees without osteoarthritis from the Osteoarthritis Initiative study.

Kamyar Moradi, Bahram Mohajer, Ali Guermazi, Roham Hadidchi, Soheil Mohammadi, Xu Cao, Mei Wan, Frank W Roemer, Shadpour Demehri

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Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kamyar MoradiThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 3142, Baltimore, MD, 21287, USA. kamyarmoradi74@gmail.com.
Bahram MohajerThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 3142, Baltimore, MD, 21287, USA.
Ali GuermaziDepartment of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Roham HadidchiThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 3142, Baltimore, MD, 21287, USA.
Soheil MohammadiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Xu CaoDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mei WanDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Frank W RoemerDepartment of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Shadpour DemehriThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 3142, Baltimore, MD, 21287, USA.

Funding

Skeleton and Joint Degeneration with AgingP01AG066603 · NIA · JOHNS HOPKINS UNIVERSITY · 2022 to 2025
$12.9M
NIAMS NIH HHS R01AR079620-01NIA NIH HHS P01AG066603
6 · The paper itself

Abstract

objectivesKnee subchondral bone marrow lesions (BMLs) are one of the hallmark features of structural osteoarthritis (OA) and are potential targets for statins' disease-modifying effect. We aimed to determine the association between statin use and longitudinal changes in magnetic resonance imaging (MRI)-based BML volume in participants without radiographic knee OA at baseline.

methodsUsing the Osteoarthritis Initiative (OAI) cohort, we classified participants' knees into two categories: statin users (those who consistently used statins from baseline to the fourth year of the cohort) and non-users. We employed a 1:1 ratio propensity score (PS) matching method, adjusting for factors including age, sex, race, BMI, smoking, alcohol use, physical activity, abdominal obesity, and diabetes mellitus. We measured quantitative BML volume using a validated deep learning (DL) algorithm, applied to baseline, year-2, and year-4 intermediate-weighted fat-saturated knee MRIs. The outcome was determined by the differences in the BML volume change between statin users and non-users over the 4-year period.

resultsAfter adjusting for potential confounders, 1502 knees were included (751 statin users and 751 non-users; mean age 63.5 ± 8.7 years, 44.5% female). A Multilevel linear mixed-effects regression model showed that statin use is associated with a smaller increase in BML volume over 4 years (time-treatment interaction effect estimates, 95% confidence interval (CI) - 14.88 mm

conclusionIn participants without baseline knee OA, continuous statin use is associated with a reduced longitudinal worsening of BML volume in the tibiofemoral joint, a known structural damage marker linked to downstream OA incidence.

Indexed as

Bone MarrowBone Marrow DiseasesHydroxymethylglutaryl-CoA Reductase InhibitorsKnee JointMagnetic Resonance ImagingOsteoarthritis, KneeAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedHydroxymethylglutaryl-CoA Reductase InhibitorsBone marrow lesionKnee osteoarthritisStatin

Identifiers

PMID39890641

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.