Evidence map›Paper›PMID 39890951›Full record

ArticleScientific reports2025

Plasma galectin-3 can be considered as a non-invasive marker to predict the prognosis of ACLF patients with new typing.

Li Bai, Wang Lu, Qi Yang, Xiaoxuan Liu, Yu Chen, Zhongping Duan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li Bai *Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing, 100069, China.
Wang Lu *Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing, 100069, China.
Qi YangFourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing, 100069, China.
Xiaoxuan LiuFourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing, 100069, China.
Yu ChenFourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing, 100069, China. chybeyond1071@ccmu.edu.cn.
Zhongping DuanFourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing, 100069, China. duan@ccmu.edu.cn.

Funding

Beijing Hospitals Authority's Ascent Plan DFL20221501Beijing Municipal Natural Science Foundation 7222094Beijing Municipal Natural Science Foundation 7232081Beijing You'an Hospital Construction of Talent Pool Program YARCKC2024001Construction Project of High-level Technology Talents in Public Health Discipline leader -01-12National Key Research and Development Program of China 2022YFC2304400
6 · The paper itself

Abstract

Very recently, we creatively put forward a new classification for ACLF patients, which lays the foundation for the establishment of prognostic model that can accurately predict the prognosis of ACLF patients. Herein, we found: galectin-3 levels were higher in type A ACLF patients compared to those of type B patients; galectin-3 expression was closely correlated with TBil, PTA/INR and MELD; galectin-3 is an independent predictive factor for rapid progression in ACLF, and exhibited superior predictive value for the prognosis of type A ACLF patients than MELD score; and the survival rate was remarkably higher in ACLF patients with lower galectin-3 expression. Collectively, galectin-3 can be considered as a non-invasive biomarker to predict the prognosis of ACLF patients with new typing. Our findings help advance the time window of prognosis prediction for type A and type B ACLF patients from 4 weeks to the baseline, thereby identifying ACLF patients who really need liver transplantation earlier and improving the survival of ACLF patients.

Indexed as

Acute-On-Chronic Liver FailureGalectin 3AdultBiomarkersBlood ProteinsFemaleGalectinsHumansMaleMiddle AgedPrognosisBiomarkersBlood ProteinsGalectin 3GalectinsLGALS3 protein, humanAcute-on-chronic liver failureGalectin-3New classificationPrognosis prediction

Identifiers

PMID39890951
PMCPMC11785724

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.