Evidence mapPaperPMID 39891010Full record

ArticleNature microbiology2025

Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice.

Gigliola Zanghí, Hardik Patel, Jenny L Smith, Nelly Camargo, Yeji Bae, Eva Hesping, Justin A Boddey, Kannan Venugopal, Matthias Marti, Erika L Flannery and 13 more

Abstract read
In one paragraph

Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Single-cell analysis ofbioRxiv : the preprint server for biology · 2026
    Article
  5. Frontiers in cellular and infection microbiology · 2026
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Gigliola Zanghí *Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA. gigliola.zanghi@seattlechildrens.org.ORCID http://orcid.org/0000-0002-9656-9642
Hardik Patel *Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0716-4510
Jenny L Smith *Research Scientific Computing, Seattle Children's Research Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0402-2779
Nelly CamargoCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Yeji BaeResearch Scientific Computing, Seattle Children's Research Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5952-4958
Eva HespingThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Justin A BoddeyThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-7322-2040
Kannan VenugopalInstitute for Parasitology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1620-5524
Matthias MartiInstitute for Parasitology, University of Zurich, Zurich, Switzerland.
Erika L FlanneryCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Vorada ChuenchobCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Matthew E FishbaugherCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Sebastian A MikolajczakCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Wanlapa RoobsoongMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID http://orcid.org/0000-0002-1789-0439
Jetsumon SattabongkotMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID http://orcid.org/0000-0002-3938-4588
Priya GuptaCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Lucia PazzagliCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Nastaran RezakhaniCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
William BetzCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Kiera HayesCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Debashree GoswamiCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Ashley M VaughanCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA. ashley.vaughan@seattlechildrens.org.ORCID http://orcid.org/0000-0001-5815-756X
Stefan H I KappeCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA. stefan.kappe@seattlechildrens.org.ORCID http://orcid.org/0000-0003-1540-1731

Funding

Biologically informed design of CD8+ T cell-dependent pre-erythrocytic stage malaria vaccinesU01AI155335 · NIAID · SEATTLE CHILDREN'S HOSPITAL · 2022 to 2025
$5.0M
Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1137694NIAID NIH HHS U01 AI155335U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI155335
6 · The paper itself

Abstract

Gene expression of Plasmodium falciparum (Pf) liver-stage (LS) parasites has remained poorly characterized, although they are major vaccine and drug targets. Using a human liver-chimaeric mouse model and a fluorescent parasite line (PfNF54

Indexed as

LiverMalaria, FalciparumPlasmodium falciparumTranscriptomeAnimalsDisease Models, AnimalGene Expression ProfilingHumansLife Cycle StagesMicePlasmodium vivaxProtozoan ProteinsTranscription FactorsProtozoan ProteinsTranscription Factors

Identifiers

PMID39891010
PMCPMC11790487

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.