Evidence map›Paper›PMID 39891747›Full record

Observational studyEuropean journal of nutrition2025

Plant-based diets and the risk of lung cancer: a large prospective cohort study.

Wei Wei, Shuyuan Wang, Zhen Yuan, Yifan Ren, Jiaxing Wu, Xiaohui Gao, Rong Wang, Jianxiong Li

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00339495 (Prostate Lung Colorectal and Ovarian), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00339495 active not recruitingnot on this map

Prostate Lung Colorectal and Ovarian (PLCO) Cancer Screening Trial

TypeobservationalSponsorNational Cancer Institute (NCI)Ran1998 to 2026Enrolled154,900ConditionsCancer, Death
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei Wei *Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, 100853, China.ORCID http://orcid.org/0000-0002-1465-0069
Shuyuan Wang *Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, 100853, China.
Zhen Yuan *School of Medicine, Nankai University, Tianjin, China.
Yifan Ren *Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, 100853, China.
Jiaxing WuSchool of Medicine, Nankai University, Tianjin, China.
Xiaohui GaoDepartment of Oncology, The Nuclear Industry 416 Hospital, Chengdu, China.
Rong WangDepartment of Radiation Oncology, Zhongshan City People's Hospital, No. 2, Sunwen East Road, Zhongshan, Guangdong, 528400, China. wangrongfypl@126.com.
Jianxiong LiSenior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, 100853, China. 301ljx@sina.com.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2020A1515110809National Natural Science Foundation of China 82103783National Natural Science Foundation of China 82373515
6 · The paper itself

Abstract

purposePlant-based diets are increasingly recognized for cancer prevention, yet their specific impact on lung cancer (LC) risk remains insufficiently examined. This study aims to assess the relationship between plant-based diets adherence and the incidence of LC.

methodsData from the Prostate, Lung, Colorectal, and Ovarian cancer screening trial were analyzed. The plant-based diet index (PDI) was developed to assess adherence to plant-based diets. Multivariable Cox regression model was performed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic spline (RCS) model was performed to examine risk across the PDI spectrum. Prespecified subgroup analyses identified potential modifiers, and sensitivity analyses tested the association's robustness.

resultsOf the 98,459 participants included, 1,642 developed LC over an average follow-up of 8.83 years. Higher PDI scores were associated with a lower LC risk (HR

conclusionOur findings reveal an inverse correlation between PDI and LC risk, supporting the potential benefits of plant-based diets in LC prevention. CLINICAL TRIAL REGISTRY NUMBER: ClinicalTrials.gov ID: NCT00339495 (URL: https://www. CLINICALTRIALS: gov/study/NCT00339495 ).

Indexed as

Diet, VegetarianLung NeoplasmsAgedCarcinoma, Non-Small-Cell LungDiet, Plant-BasedFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsLung cancerNutritional epidemiologyPlant-based dietsPLCO trial

Identifiers

PMID39891747
PMCPMC11787154

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.