Evidence map›Paper›PMID 39892952›Full record

ReviewClinics in perinatology2025

Circadian Rhythms, Immune Regulation, and the Risk for Sepsis: Circadian Rhythms and Neonatal Care.

Shaon Sengupta, David F Smith, Bala S C Koritala

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinics in perinatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shaon SenguptaDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, The Children's Hospital of Philadelphia, 3615 Curie Boulevard, Abramson Research Building, 1102C, Philadelphia, PA 19104, USA. Electronic address: SenguptaS@chop.edu.
David F SmithDivision of Pediatric Otolaryngology-Head and Neck Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Bala S C KoritalaDivision of Pediatric Otolaryngology-Head and Neck Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

Funding

Mechanistic evaluation of the role of circadian rhythms in acute lung injury and subsequent recoveryR01HL155934 · CHILDREN'S HOSP OF PHILADELPHIA · 2025 to 2025
$535k
NHLBI NIH HHS K08 HL148551NHLBI NIH HHS R01 HL155934
6 · The paper itself

Abstract

Circadian rhythms provide an anticipatory mechanism for organisms to adapt to environmental changes. Host response to infections is under robust circadian control. Most of the existing literature focuses on adults in epidemiologic and animal studies. Neonatal and early infancy represent critical windows in the consolidation of circadian rhythms. This review summarizes our understanding of the molecular clock, especially its relevance to immunity and adult sepsis. Further, using our knowledge of circadian biology in caring for a newborn host with emerging circadian rhythms represents a unique challenge and an opportunity for improving our approach and outcomes in neonatal sepsis.

Indexed as

Circadian RhythmNeonatal SepsisSepsisAnimalsHumansInfant, NewbornChronobiologyCircadian rhythmsImmunityInfectionSepsis

Identifiers

PMID39892952
PMCPMC11788575

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.