Evidence map›Paper›PMID 39893305›Full record

ArticleNPJ digital medicine2025

Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers.

Julia C Spinelli, Brandon J Suleski, Donald E Wright, Joseph L Grow, Gabriel R Fagans, Maura J Buckley, Da Som Yang, Kaitao Yang, Steven M Beil, Jessica C Wallace and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Review
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  4. Microfluidic valves for wearable sweat analysis: a review.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
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  13. Review
  14. Article
  15. Review
  16. Review
  17. Wireless arm-worn bioimpedance sensor for continuous assessment of whole-body hydration.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Julia C Spinelli *Epicore Biosystems, Inc, Cambridge, MA, USA.
Brandon J Suleski *Epicore Biosystems, Inc, Cambridge, MA, USA.
Donald E Wright *Epicore Biosystems, Inc, Cambridge, MA, USA.
Joseph L GrowEpicore Biosystems, Inc, Cambridge, MA, USA.
Gabriel R FagansEpicore Biosystems, Inc, Cambridge, MA, USA.
Maura J BuckleyEpicore Biosystems, Inc, Cambridge, MA, USA.
Da Som YangQuerrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Kaitao YangEpicore Biosystems, Inc, Cambridge, MA, USA.
Steven M BeilEpicore Biosystems, Inc, Cambridge, MA, USA.
Jessica C WallaceEpicore Biosystems, Inc, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2654-7149
Thomas S DiZoglioEpicore Biosystems, Inc, Cambridge, MA, USA.
Jeffrey B ModelEpicore Biosystems, Inc, Cambridge, MA, USA.
Shirley LoveEpicore Biosystems, Inc, Cambridge, MA, USA.
David E MacintoshEpicore Biosystems, Inc, Cambridge, MA, USA.
Alan P ScarthEpicore Biosystems, Inc, Cambridge, MA, USA.
Matthew T MarrapodeEpicore Biosystems, Inc, Cambridge, MA, USA.
Corinna ServienteInstitute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Raudel AvilaDepartment of Mechanical Engineering, Rice University, Houston, TX, USA.
Barrak K AlahmadDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Michael A BusaInstitute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
John A WrightEpicore Biosystems, Inc, Cambridge, MA, USA.
Weihua LiEpicore Biosystems, Inc, Cambridge, MA, USA.
Douglas J CasaDepartment of Kinesiology, University of Connecticut, Storrs, CT, USA.
John A RogersQuerrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
Stephen P LeeEpicore Biosystems, Inc, Cambridge, MA, USA. stever@epicorebiosystems.com.ORCID http://orcid.org/0000-0002-8521-8652
Roozbeh GhaffariEpicore Biosystems, Inc, Cambridge, MA, USA. rooz@northwestern.edu.ORCID http://orcid.org/0000-0001-5380-2363
Alexander J AranyosiEpicore Biosystems, Inc, Cambridge, MA, USA. aja@epicorebiosystems.com.ORCID http://orcid.org/0000-0002-8133-5026

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-time monitoring of hydration biomarkers in tandem with biophysical markers can offer valuable physiological insights about heat stress and related thermoregulatory response. These metrics have been challenging to achieve with wearable sensors. Here we present a closed-loop electrochemical/biophysical wearable sensing device and algorithms that directly measure whole-body sweat loss, sweating rate, sodium concentration, and sodium loss with electrode arrays embedded in a microfluidic channel. The device contains two temperature sensors for skin temperature and thermal flux recordings, and an accelerometer for real-time monitoring of activity level. An onboard haptic module enables vibratory feedback cues to the wearer once critical sweat loss thresholds are reached. Data is stored onboard in memory and autonomously transmitted via Bluetooth to a smartphone and cloud portal. Field studies conducted in physically demanding activities demonstrate the key capabilities of this platform to inform hydration interventions in highly challenging real-world settings.

Identifiers

PMID39893305
PMCPMC11787291

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.