Evidence map›Paper›PMID 39893593›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Association between Helicobacter pylori, reflux and chronic rhinosinusitis: a systematic review.

Jerome R Lechien, Kamal Ragrag, Jason Kasongo, Valentin Favier, Miguel Mayo-Yanez, Carlos M Chiesa-Estomba, Giannicola Iannella, Giovanni Cammaroto, Alberto M Saibene, Luigi A Vaira and 6 more

Abstract readSystematic ReviewReview
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jerome R Lechien *Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. Jerome.Lechien@umons.ac.be.ORCID http://orcid.org/0000-0002-0845-0845
Kamal Ragrag *Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.
Jason Kasongo *Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.
Valentin FavierResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Miguel Mayo-YanezResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Carlos M Chiesa-EstombaResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Giannicola IannellaResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Giovanni CammarotoResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Alberto M SaibeneResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Luigi A VairaResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Florent CarsuzaaResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Kalamkas SagandykovaResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Maxime FieuxResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Quentin LisanDepartment of Otolaryngology-Head Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.
Stephane HansDepartment of Otolaryngology-Head Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.
Antonino ManiaciResearch Committee, Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence, role, and clinical relevance of Helicobacter Pylori (HP) in sinonasal tissues of patients with chronic rhinosinusitis remain unclear.

objectiveTo investigate the prevalence and clinical relevance of Helicobacter Pylori (HP) in chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and without nasal polyps (CRSSNP).

methodsThree investigators conducted a PubMed, Scopus, and Cochrane Library systematic review of the prevalence and clinical relevance of HP infection in CRS patients through the PRISMA framework. A bias analysis was conducted to identify potential heterogeneity and biases across studies.

resultsOf the 42 identified studies, 20 met the inclusion criteria, accounting for 741 CRS patients and 368 controls. HP was detected in 37.1% (n = 127/342) of polyps of CRSwNP patients with the polymerase chain reaction (PCR) and 32.7% (n = 37/113) of polyp tissue with the immunohistochemistry (IHC). Controls reported a nasal PCR and IHC detection rates of 14.8% (n = 36/243) and 3.6% (n = 3/84), respectively. The HP rate did not differ between CRSwNP and CRSsNP. Among patients with CRS, the enzyme-linked immunosorbent assay testing detected blood HP antigens in 48.7% (n = 74/152) of CRS patients and 41.6% (n = 37/89) of controls. The detection of HP in polyps was associated with the severity of gastroesophageal reflux disease (GERD). There was an important heterogeneity between studies for the inclusion criteria, methods of HP detection, and reflux outcomes.

conclusionHelicobacter Pylori can be detected in one-third of sinonasal tissues from patients with CRS and can be considered a biomarker of GERD. The potential role of HP in the development of CRS remains unclear. The heterogeneity between studies limits the drawing of valid conclusions.

Indexed as

Gastroesophageal RefluxHelicobacter InfectionsHelicobacter pyloriNasal PolypsRhinitisSinusitisChronic DiseaseHumansPrevalenceRhinosinusitisChronic RhinosinusitisGastroesophagealHelicobacter PyloriLaryngopharyngealOtolaryngologyOtorhinolaryngologyPolypReflux

Identifiers

PMID39893593

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.