ArticleJournal of the American Heart Association2025
In Patients With Hypertension, the Cortical Perfusion Index Measured by Contrast Enhanced Ultrasound Reveals a Sexual Dimorphism.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Preliminary exploration of quantitative analysis parameters of renal cortical blood perfusion by contrast-enhanced ultrasound in hypertensive patients.Quantitative imaging in medicine and surgery · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundArterial hypertension is characterized by microvasculature changes and reduced tissue perfusion. It is unknown whether a sexual dimorphism of renal microcirculation is present in patients with arterial hypertension. We aimed to compare the cortical microcirculation in women and men with hypertension and to evaluate their response to sympathetic stimulation with a cold pressor test (CPT).
methodsThe cortical perfusion index (PI) measured by contrast-enhanced ultrasonography was used as a proxy of renal microcirculation. We measured the PI at rest and during a 2-minute CPT in patients with arterial hypertension. We used a linear mixed-model analysis to study the effect of sex, the CPT, and their interaction on the PI.
resultsThirty-two participants were included (34% women). Age and body mass index were similar in both groups. Median PI was higher in women (2344 [interquartile range, 1553-2685 arbitrary units]) than men (1285 [interquartile range, 591-1741 arbitrary units],
conclusionsWomen with arterial hypertension have a higher cortical microperfusion than men, while their microvascular reactivity to a CPT appears to be similar. This sexual dimorphism may have an impact on renal function decline, which needs further investigation.
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