Evidence map›Paper›PMID 39895759›Full record

ReviewACS omega2025

Zinc from an Essential Element to an Antiparasitic Therapeutic Agent.

Maribel Navarro, Luana Vanessa Daniel, Legna Colina-Vegas, Gonzalo Visbal

Abstract readReview
In one paragraph

Review in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Complexes of Zinc(II) Chloride withPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maribel NavarroLaboratório de Químicas Bioinorgânica e Catalise (LaQBIC), Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora Juiz de Fora, Juiz de Fora 36036-900, Brazil.ORCID https://orcid.org/0000-0002-8772-0312
Luana Vanessa DanielLaboratório de Químicas Bioinorgânica e Catalise (LaQBIC), Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora Juiz de Fora, Juiz de Fora 36036-900, Brazil.
Legna Colina-VegasInstituto de Química, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.
Gonzalo VisbalLaboratório de Ácidos Nucleicos (Laban), Coordenação Geral de Biologia (Cobio), Diretoria de Metrologia, Científica e Industrial, DIMCI, Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Rio de Janeiro 25250-020, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tropical parasitic diseases affect millions of people around the world, particularly in poor countries. The human parasitic diseases that will be covered in this review are malaria and neglected diseases, such as leishmaniasis, Chagas disease, and African trypanosomiasis. The current treatments for these diseases present several problems, such as the development of drug resistance, very limited drugs available in the clinic, significant side effects of the drugs, and a long treatment period. For these reasons, there is an urgent need to develop new chemotherapeutics to eradicate or eliminate these diseases. Zinc-based drugs against parasitic diseases could be an alternative therapy to overcome the difficulties of the approved metallodrugs as antiparasitic agents. Zinc-based drugs are becoming an exciting field of research because zinc is an essential element that can lead to the development of multitarget antiparasitic agents, which are reviewed here.

Identifiers

PMID39895759
PMCPMC11780429

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.