Evidence map›Paper›PMID 39896107›Full record

ArticleBone reports2025

Ischemic stroke reduces bone perfusion and alters osteovascular structure.

Nicholas J Hanne, Andrew J Steward, Carla Geeroms, Elizabeth D Easter, Hannah T Gensch, Greet Kerckhofs, Tatjana N Parac-Vogt, Huaxin Sheng, Jacqueline H Cole

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicholas J HanneJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, and North Carolina State University, Raleigh, NC, USA.
Andrew J StewardJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, and North Carolina State University, Raleigh, NC, USA.
Carla GeeromsPrometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.
Elizabeth D EasterMaterials Science and Engineering, North Carolina State University, Raleigh, NC, USA.
Hannah T GenschJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, and North Carolina State University, Raleigh, NC, USA.
Greet KerckhofsPrometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.
Tatjana N Parac-VogtDepartment of Chemistry, KU Leuven, Leuven, Belgium.
Huaxin ShengDepartment of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Jacqueline H ColeJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, and North Carolina State University, Raleigh, NC, USA.

Funding

Interdisciplinary Engineering Career Development Center in Movement and Rehabilitation SciencesK12HD073945 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEWALD, JULIUS P, REINKENSMEYER, DAVID JAY · 2012 to 2021
$7.9M
NICHD NIH HHS K12 HD073945
6 · The paper itself

Abstract

Stroke patients lose bone mass and experience fracture at an elevated rate. Although functional intraosseous vasculature is necessary for skeletal maintenance, the effect of stroke on osteovasculature is unknown. In this study we characterized changes to osteovascular perfusion, structure, and composition following mild-to-moderate stroke severity in mice, both with and without exercise therapy. Twelve-week-old male mice (

Indexed as

Bone vasculatureIntraosseous perfusionIschemic stroke

Identifiers

PMID39896107
PMCPMC11782850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.