ArticlebioRxiv : the preprint server for biology2025
Gut Competition Dynamics of Live Bacterial Therapeutics Are Shaped by Microbiome Complexity, Diet, and Therapeutic Transgenes.
Nicole Siguenza, Sharyl Bailey, Mohammad Sadegi, Hanna Gootin, Maria Tiu, Jeffrey D Price, Amanda Ramer-Tait, Amir Zarrinpar
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Nicole SiguenzaDivision of Gastroenterology, University of California, San Diego, La Jolla, CA, USA.
Sharyl BaileyDivision of Gastroenterology, University of California, San Diego, La Jolla, CA, USA.
Mohammad SadegiDivision of Gastroenterology, University of California, San Diego, La Jolla, CA, USA.
Hanna GootinDivision of Gastroenterology, University of California, San Diego, La Jolla, CA, USA.
Maria TiuDivision of Gastroenterology, University of California, San Diego, La Jolla, CA, USA.
Jeffrey D PriceDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Amanda Ramer-TaitDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Funding
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3MViral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8MThe Role of Altered Luminal Dynamics in OSA-Induced AtherosclerosisR01HL148801 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZARRINPAR, AMIR · 2019 to 2023
$4.0MEngineering Native E. coli to Detect, Report, and Treat Colorectal CancerU01CA265719 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZARRINPAR, AMIR · 2021 to 2025
$3.1MDevelopment of Engineered Native Bacteria as a Tool for Functional Manipulation of the Gut MicrobiomeR01AI163483 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEFF M HASTY, Amir Zarrinpar · 2023 to 2026
$3.1MDesign and characterization of bacterial population dynamics in solid tumor modelsR01EB030134 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HASTY, JEFF M, TSIMRING, LEV S · 2021 to 2024
$2.5MBLRD VA I01 BX005707NCATS NIH HHS UL1 TR001442NCI NIH HHS P30 CA014195NCI NIH HHS U01 CA265719NHLBI NIH HHS R01 HL148801NIAID NIH HHS R01 AI163483NIBIB NIH HHS R01 EB030134NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK120515
6 · The paper itselfAbstract
Competitive exclusion is conventionally believed to prevent the establishment of a secondary strain of the same bacterial species in the gut microbiome, raising concerns for the deployment of live bacterial therapeutics (LBTs), especially if the bacterial chassis is a strain native to the gut. In this study, we investigated factors influencing competition dynamics in the murine gut using isogenic native
Indexed as
bile salt hydrolasegnotobiotichost-microbe interactionsintestinal inflammationmetabolic burdenMicrobiome-based therapiesnative chassisniche adaptationprecision medicinesynthetic biology
Identifiers
PMID39896492
PMCPMC11785071
What Socratic holds
Textmetadata
Read underepoch 390