Evidence map›Paper›PMID 39896606›Full record

ArticlebioRxiv : the preprint server for biology2025

Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium.

O Pellon-Cardenas, P Rout, S Hassan, E Fokas, He Ping, I Patel, J Patel, O Plotsker, A Wu, R Kumar and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

O Pellon-CardenasDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
P RoutDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
S HassanDepartment of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
E FokasDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
He PingDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
I PatelDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
J PatelDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
O PlotskerDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
A WuDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
R KumarDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
M AktherDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
A LogerfoDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
S WuDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
D E WagnerDepartment of Obstetrics, University of California, San Francisco, San Francisco, CA, USA.
D BoffelliDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA.
K D WaltonDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
E ManieriDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
K TongDepartment of Medical Sciences, Hackensack Meridian Health School of Medicine, Nutley, NJ, USA.
J R SpenceDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
N J BessmanDepartment of Medicine, New Jersey Medical School, Rutgers, Newark, NJ, USA.
R A ShivdasaniDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-2828-1727
M P VerziDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0003-4082-4330

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
Niche support of human intestinal stem cellsU01DK103141 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCE, JASON · 2014 to 2023
$3.9M
Transcriptional Mechanisms of Tumor SuppressionR01CA190558 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI MICHAEL P. VERZI · 2015 to 2026
$3.6M
Rutgers Biotechnology Training ProgramT32GM135141 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANN M. STOCK, Martin L Yarmush · 2020 to 2026
$3.5M
Mechanisms of Hedgehog Regulation of Intestinal Villus MorphogenesisR01DK121166 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTON, KATHERINE DEMPSEY · 2019 to 2023
$1.8M
NCI NIH HHS P30 CA072720NCI NIH HHS R01 CA190558NIDDK NIH HHS R01 DK121166NIDDK NIH HHS U01 DK103141NIGMS NIH HHS T32 GM135141
6 · The paper itself

Abstract

Stromal fibroblasts regulate critical signaling gradients along the intestinal crypt-villus axis

Indexed as

Colon cancerfetal-likeintestinal stromaregenerativereprogrammingTGFB signalingWNT signaling

Identifiers

PMID39896606
PMCPMC11785226

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.