Evidence map›Paper›PMID 39896714›Full record

ArticleIBRO neuroscience reports2025

Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank.

Panlong Li, Xirui Zhu, Chun Huang, Shan Tian, Yuna Li, Yuan Qiao, Min Liu, Jingjing Su, Dandan Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Panlong LiSchool of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Xirui ZhuSchool of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Chun HuangSchool of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Shan TianDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuna LiDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuan QiaoDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Min LiuDepartment of Hypertension, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.
Jingjing SuDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dandan TianDepartment of Hypertension, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the impact of obesity on brain structure and cognition using large neuroimaging and genetic data. Methods: Associations between body mass index (BMI), gray matter volume (GMV), whiter matter hyper-intensities (WMH), and fluid intelligence score (FIS) were estimated in 30283 participants from the UK Biobank. Longitudinal data analysis was conducted. Genome-wide association studies were applied to explore the genetic loci associations among BMI, GMV, WMH, and FIS. Mendelian Randomization analyses were applied to further estimate the effects of obesity on changes in the brain and cognition. Results: The observational analysis revealed that BMI was negatively associated with GMV (r = -0.15, p < 1 Conclusions: The phenotypic and genetic association between obesity and aging brain and cognitive decline suggested that weight control could be a promising strategy for slowing the aging brain.

Indexed as

Genetic overlapGray matter atrophyMendelian randomizationObesityWhite matter hyper-intensities

Identifiers

PMID39896714
PMCPMC11786748

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.