Evidence map›Paper›PMID 39896840›Full record

ReviewBrain, behavior, & immunity - health2025

Lipid mediators in post-mortem brain samples from patients with Alzheimer's disease: A systematic review.

Aidan D Tyrrell, Giulia Cisbani, Mackenzie E Smith, Chuck T Chen, Yue-Tong Chen, Raphael Chouinard-Watkins, Kathryn E Hopperton, Ameer Y Taha, Richard P Bazinet

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aidan D TyrrellDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Canada.
Giulia CisbaniDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Canada.
Mackenzie E SmithDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Canada.
Chuck T ChenDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Canada.
Yue-Tong ChenDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Canada.
Raphael Chouinard-WatkinsDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Canada.
Kathryn E HoppertonDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Canada.
Ameer Y TahaDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.
Richard P BazinetDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A proposed contributor to Alzheimer's disease (AD) pathology is the induction of neuroinflammation due to tau and beta-amyloid protein accumulation causing neuronal injury and dysfunction. Dysregulation of lipid mediators derived from polyunsaturated fatty acids may contribute to this inflammatory response in the brain of patients with AD, yet the literature has not yet been systematically reviewed. A systematic search was conducted in Medline, Embase and PsychINFO for articles published up to April 22, 2024. Papers were included if they measured levels of lipid mediators and/or enzymes involved in their production in

Indexed as

Alzheimer's diseaseLipid mediatorsNeuroinflammationPost-mortem

Identifiers

PMID39896840
PMCPMC11782888

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.