Evidence map›Paper›PMID 39897024›Full record

ArticleInternational journal of biological sciences2025

Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling.

Haina Zhang, Wenqian Zhou, Xiang Wang, Hongbo Men, Jiqun Wang, Jianxiang Xu, Shanshan Zhou, Quan Liu, Lu Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Zinc: a metallic shield against cardiac inflammation.Metallomics : integrated biometal science · 2026
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haina ZhangPediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA.
Wenqian ZhouPediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA.
Xiang WangPediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA.
Hongbo MenPediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA.
Jiqun WangPediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA.
Jianxiang XuPediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA.
Shanshan ZhouDepartment of Cardiovascular Diseases, The First Hospital of Jilin University, Jilin University, Changchun, 130021, China.
Quan LiuDepartment of Cardiovascular Diseases, The First Hospital of Jilin University, Jilin University, Changchun, 130021, China.
Lu CaiPediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA.

Funding

University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
NIEHS NIH HHS P30 ES030283
6 · The paper itself

Abstract

Obesity increases the risk of metabolic syndrome including insulin resistance, dyslipidemia, and cardiovascular disease. We demonstrated insulin resistance, cardiac hypertrophy, and cardiac inflammation in an obese mouse model induced by a high-fat diet (HFD). Caspase recruitment domain-containing protein 9 (CARD9) and B-cell lymphoma/leukemia 10 (BCL10) were upregulated, and p38 MAPK was activated in these mice. Zinc supplementation prevented these changes with upregulation of metallothionein (MT). Deletion of

Indexed as

CARD Signaling Adaptor ProteinsMetallothioneinObesityVentricular RemodelingAnimalsB-Cell CLL-Lymphoma 10 ProteinCardiomegalyDiet, High-FatMaleMiceMice, Knockoutp38 Mitogen-Activated Protein KinasesSignal TransductionB-Cell CLL-Lymphoma 10 ProteinBcl10 protein, mouseCard9 protein, mouseCARD Signaling Adaptor ProteinsMetallothioneinp38 Mitogen-Activated Protein KinasesCARD9Cardiac remodelingInflammationMetallothioneinObesity cardiomyopathy

Identifiers

PMID39897024
PMCPMC11781176

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.