Evidence map›Paper›PMID 39897041›Full record

ArticleInternational journal of biological sciences2025

Ugonin inhibits chondrosarcoma metastasis through suppressing cathepsin V via promoting miR-4799-5p expression.

Nguyen Bao Tran, Ting-Kuo Chang, Nguyen Duong Phuong Chi, Kuan-Ying Lai, Hsien-Te Chen, Yi-Chin Fong, Chih-Chuang Liaw, Chih-Hsin Tang

Abstract read
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nguyen Bao TranGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, 404.
Ting-Kuo ChangDepartment of Medicine, Mackay Medical College, New Taipei, Taiwan, 252.
Nguyen Duong Phuong ChiDepartment of Chinese Pharmaceutical Science and Chinese Medicine Resources, China Medical University, Taichung, Taiwan, 404.
Kuan-Ying LaiDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, 80424.
Hsien-Te ChenDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan, 404.
Yi-Chin FongDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan, 404.
Chih-Chuang LiawDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, 80424.
Chih-Hsin TangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, 404.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chondrosarcoma is a rare type of bone cancer that develops in cartilage cells. In recent years, the incidence of chondrosarcomas has steadily increased worldwide. During the advanced stages, chondrosarcoma carries a significant risk of metastasis and exhibits resistance to both chemotherapy and radiation therapy. Hence, the development of potent treatments for chondrosarcoma is an urgent requirement. Ugonin V is a flavonoid compound that has been extracted from the plant

Indexed as

Bone NeoplasmsCathepsinsChondrosarcomaFlavonoidsMicroRNAsAnimalsCell Line, TumorCell MovementCysteine EndopeptidasesGene Expression Regulation, NeoplasticHumansMiceMice, NudeNeoplasm MetastasisCathepsinsCTSV protein, humanCysteine EndopeptidasesFlavonoidsMicroRNAscathepsin VchondrosarcomametastasismiR-4799-5pugonin V

Identifiers

PMID39897041
PMCPMC11781170

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.