Evidence map›Paper›PMID 39897056›Full record

ArticleComputational and structural biotechnology journal2025

Plasticity of BioPhi-driven humanness optimization in ScFv-CD99 binding affinity validated through AlphaFold, HADDOCK, and MD simulations.

Kanokporn Sornsuwan, Thanathat Pamonsupornwichit, On-Anong Juntit, Weeraya Thongkum, Nuchjira Takheaw, Kanchanok Kodchakorn, Chatchai Tayapiwatana

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Experimental and Mechanistic Validation of PARP1pred for Identifying Potent Leads.Computational and structural biotechnology journal · 2026
    Article
  2. Review
  3. AlphaFold in protein structure and function prediction.Computational and structural biotechnology journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kanokporn SornsuwanOffice of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Thanathat PamonsupornwichitCenter of Biomolecular Therapy and Diagnostic, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
On-Anong JuntitOffice of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Weeraya ThongkumOffice of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Nuchjira TakheawBiomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency at the Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Kanchanok KodchakornOffice of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Chatchai TayapiwatanaCenter of Biomolecular Therapy and Diagnostic, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BioPhi-guided humanization was utilized to enhance the humanness of a humanized single-chain variable fragment targeting CD99, leading to the development of two variants: HuScFvMT99/3

Indexed as

AlphaFoldBinding affinityBioPhiHADDOCKHumanized ScFvMD simulations

Identifiers

PMID39897056
PMCPMC11786912

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.