Evidence map›Paper›PMID 39897544›Full record

ArticleTheranostics2025

Exosomes of human adipose stem cells mitigate irradiation injury to salivary glands by inhibiting epithelial-mesenchymal transition through miR-199a-3p targeting Twist1 and regulating TGFβ1/Smad3 pathway.

Xiaotong Guo, Zhu Huang, Fan Wu, Wentao Jiang, Yiyang Li, Tao Wang, Simon D Tran, Zhengmei Lin, Xinyun Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Exosomes in ocular graft-versus-host disease: an overview.International journal of ophthalmology · 2026
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaotong GuoHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Institute of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Zhu HuangHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Institute of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Fan WuHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Institute of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Wentao JiangHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Institute of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Yiyang LiHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Institute of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Tao WangHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Institute of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Simon D TranMcGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC H3A0C7, Canada.
Zhengmei LinHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Institute of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Xinyun SuHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Institute of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Epithelial-Mesenchymal TransitionExosomesMicroRNAsNuclear ProteinsSalivary GlandsTwist-Related Protein 1Adipose TissueAnimalsCell ProliferationHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLSignal TransductionSmad3 ProteinMicroRNAsmirn199 microRNA, humanNuclear ProteinsSmad3 ProteinSMAD3 protein, humanTGFB1 protein, humanTransforming Growth Factor beta1TWIST1 protein, humanTwist-Related Protein 1epithelial-mesenchymal transitionexosomesradiationsalivary glandsstem cell

Identifiers

PMID39897544
PMCPMC11780531

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.