Evidence map›Paper›PMID 39897639›Full record

ArticleMolecular therapy. Methods & clinical development2025

mTOR downregulation promotes anti-inflammatory responses via the CCL3-CCR5 axis in hypoxic retinopathy.

Tae Kwon Moon, Im Kyeung Kang, Kyoung Jin Lee, Ji Hyun Kim, Hee Jong Kim, A Reum Han, Ha-Na Woo, Joo Yong Lee, Jun-Sub Choi, Keerang Park and 1 more

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Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tae Kwon MoonAsan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Im Kyeung KangAsan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kyoung Jin LeeDepartment of Microbiology, University of Ulsan, College of Medicine, Seoul, Republic of Korea.
Ji Hyun KimDepartment of Microbiology, University of Ulsan, College of Medicine, Seoul, Republic of Korea.
Hee Jong KimInstitute of New Drug Development Research, CdmoGen Co., Ltd., Seoul 05854, Republic of Korea.
A Reum HanAsan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Ha-Na WooBio-Medical Institute of Technology, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Joo Yong LeeBio-Medical Institute of Technology, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Jun-Sub ChoiInstitute of New Drug Development Research, CdmoGen Co., Ltd., Seoul 05854, Republic of Korea.
Keerang ParkInstitute of New Drug Development Research, CdmoGen Co., Ltd., Seoul 05854, Republic of Korea.
Heuiran LeeBio-Medical Institute of Technology, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxic retinopathies, including diabetic retinopathy, are major contributors to vision impairment, mainly due to accelerated angiogenesis and inflammation. Previously, we demonstrated that AAV2-shmTOR, effective across distinct species, holds therapeutic promise by modulating the activated mTOR pathway, yet its mechanisms for reducing inflammation remain largely unexplored. To investigate AAV2-shmTOR's impact on atypical inflammation in these conditions, we employed an

Indexed as

adeno-associated virusCCL3CCR5gene therapyhypoxiamTORretinopathysmall interfering RNA

Identifiers

PMID39897639
PMCPMC11787640

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.