Evidence map›Paper›PMID 39898049›Full record

ArticleiScience2025

Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice.

Oliver K Fuller, Emma D McLennan, Casey L Egan, Nimna Perera, Lauren V Terry, Jae Pyun, Mariana de Mendonca, Guilherme Defante Telles, Benoit Smeuninx, Emma L Burrows and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)-Enriched Extracellular Vesicles That Promote Angiogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Oliver K FullerMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Emma D McLennanMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Casey L EganMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Nimna PereraMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Lauren V TerryMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Jae PyunMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Mariana de MendoncaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Guilherme Defante TellesMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Benoit SmeuninxMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Emma L BurrowsFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Ghizal SiddiquiMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Darren J CreekMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
John W ScottMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Michael A PearenQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Pamali FonsekaLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Joseph A NicolazzoMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Suresh MathivananLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Anthony J HannanFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Grant A RammQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Martin WhithamSchool of Sport, Exercise & Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
Mark A FebbraioMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise improves cognitive function in Alzheimer's disease (AD) via mechanism that are not fully clear. Here, we first examined the effect of voluntary exercise training (VET) on energy metabolism and cognitive function in the APP/PS1 transgenic mouse (Tg) model of familial AD. Next, we profiled extracellular vesicles (EVs) and examined whether they may play a role in the protective effects of VET via intranasal administration of EVs, purified from the blood of sedentary (sEV) and/or acutely exercised (eEV) donor wild-type mice into APP/PS1Tg mice. We show that VET reduced resting energy expenditure (REE) and improved cognition in APP/PS1 Tg mice. Administration of eEV, but not sEV, also reduced REE, but had no effect on cognition. Taken together, these data show that exercise is effective intervention to improve symptoms of AD in APP/PS1Tg mice. In addition, eEVs mediate some of these effects, implicating EVs in the treatment of age-related neurodegenerative diseases.

Indexed as

Cell biologyMolecular physiologyNeuroscience

Identifiers

PMID39898049
PMCPMC11787611

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.