Evidence map›Paper›PMID 39898462›Full record

ArticlePediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

Genetically Distinct Acute Megakaryoblastic Leukemia following Low Hypodiploid B-Lymphoblastic Leukemia linked by

Jaryse C Harris, Jeffrey Schubert, Brian Lockhart, Rachel Olson, Michele E Paessler, Elizabeth Margolskee, Vinodh Pillai, Jinhua Wu, Netta Golenberg, Jiani Chen and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jaryse C HarrisDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0005-7235-3539
Jeffrey SchubertDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Brian LockhartDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Rachel OlsonDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Michele E PaesslerDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Elizabeth MargolskeeDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Vinodh PillaiDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Jinhua WuDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Netta GolenbergDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jiani ChenDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Elizabeth H DenenbergDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tammy LukeDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Minjie LuoDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yiming ZhongDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Marilyn M LiDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Gerald B WertheimDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of acute myeloid leukemia with megakaryoblastic differentiation (AMKL) that developed after an initial B-lymphoblastic leukemia (B-ALL) with low hypodiploidy. Although the AMKL was initially thought either to be a phenotypic change from the original B-ALL or to have arisen as a result of treatment (acute myeloid leukemia, post cytotoxic therapy, AML-pCT [WHO]; AML, therapy related [ICC]), genetic evaluation of both the AMKL and the B-ALL suggest that neither of these considerations was correct. Rather, the AMKL did not harbor the most common genetic hallmark of AML-pCT-rearrangement of

Indexed as

Leukemia, Megakaryoblastic, AcuteMutationPrecursor B-Cell Lymphoblastic Leukemia-LymphomaTumor Suppressor Protein p53FemaleHumansMaleTP53 protein, humanTumor Suppressor Protein p53acute megakaryoblastic leukemiahematopathologylow hypodiploid B-lymphoblastic leukemiamolecular oncologymolecular pathologyTP53 mutation

Identifiers

PMID39898462
PMCPMC12053263

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.