Evidence map›Paper›PMID 39900508›Full record

ArticleeNeuro2025

Limiting Hearing Loss in Transgenic Mouse Models.

Travis A Babola, Naomi Donovan, Sean S Darcy, Catalina D Spjut, Patrick O Kanold

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Travis A BabolaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205.ORCID https://orcid.org/0000-0003-4440-5029
Naomi DonovanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205.
Sean S DarcyDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205.
Catalina D SpjutDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205.ORCID https://orcid.org/0009-0009-7516-3158
Patrick O KanoldDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205 pkanold@jhu.edu.ORCID https://orcid.org/0000-0002-7529-5435

Funding

NEURONAL CIRCUITS AND PLASTICITY OF NEONATAL AUDITORY CORTEXR01DC009607 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI PATRICK O KANOLD · 2009 to 2026
$7.8M
Dynamic processing of sound in auditory cortexR01DC017785 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI KANOLD, PATRICK O · 2021 to 2025
$2.7M
Plasticity of Functional Networks in Auditory CortexF32DC019842 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI BABOLA, TRAVIS AUSTIN · 2021 to 2022
$136k
NIDCD NIH HHS F32 DC019842NIDCD NIH HHS R01 DC009607NIDCD NIH HHS R01 DC017785
6 · The paper itself

Abstract

Transgenic mice provide unprecedented access to manipulate and visualize neural circuits; however, those on a C57BL/6 background develop progressive hearing loss, significantly confounding systems-level and behavioral analysis. While outbreeding can limit hearing loss, it introduces strain variability and complicates the generation of complex genotypes. Here, we propose an approach to preserve hearing by crossing transgenic mice with congenic B6.CAST-

Indexed as

Auditory CortexDisease Models, AnimalHearing LossAcoustic StimulationAnimalsAuditory ThresholdCadherinsFemaleMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsCadherinsCdh23 protein, mousebehaviordeafhearing lossmousetransgenic

Identifiers

PMID39900508
PMCPMC11875052

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.