ArticleScientific reports2025
Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs -micro-CT with contrast study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Protocol for Post-Mortem Micro-CT Imaging of Coronary Arteries in Low-Mass Neonatal Puppy Hearts Using Barium-Based Contrast.Animals : an open access journal from MDPI · 2026Article
- Severe pulmonary trunk stenosis associated with R2A-type coronary artery anomaly in a dog: echocardiographic findings and post-mortem contrast-enhanced CT confirmation.BMC veterinary research · 2026Article
- Double inlet left ventricle in a 12-year-old European bison: a case report with anatomical assessment and postmortem computed tomography evaluation.BMC veterinary research · 2025Article
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Authors and funding
14 authors.
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Abstract
Limited data are available on the causes of hydrops fetalis in dogs. Congenital heart defects may be an important contributing factor. Standard autopsy often fails to provide a comprehensive and accurate diagnosis on very small hearts. This study was carried out on five French bulldog puppies all presenting with advanced hydrops fetalis and four diagnosed with pulmonary hypoplasia at autopsy. The body weight of the dogs ranged from 142 to 687 g and the heart with lungs weighed from 4.5 to 23.6 g. The hearts and pulmonary vessels were filled with barium contrast, and micro-CT scans of the physiologically connected heart and lungs were performed. In all five puppies, we confirmed congenital heart defects including: Puppy #1. Perimembranous ventricular septal defect and aortic dextroposition; Puppy #2. Interrupted aortic arch with aortic valve dysplasia and aortic stenosis; Puppy #3. Tricuspid valve dysplasia and bicuspid pulmonary trunk valve; Puppy #4. Aortic stenosis and ventricular septal defect; Puppy #5. Tricuspid valve dysplasia. Additionally, four puppies had pulmonary vascular hypoplasia. Contrast-enhanced micro-CT can provide highly accurate diagnosis of complex congenital heart and lung defects. Examination of the heart in conjunction with the lungs appears to be a rational approach in animals with hydrops fetalis.
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