Evidence map›Paper›PMID 39900737›Full record

ArticleNature materials2025

Printable molecule-selective core-shell nanoparticles for wearable and implantable sensing.

Minqiang Wang, Cui Ye, Yiran Yang, Daniel Mukasa, Canran Wang, Changhao Xu, Jihong Min, Samuel A Solomon, Jiaobing Tu, Guofang Shen and 5 more

Abstract read
In one paragraph

Article in Nature materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Multiscale Manufacturing of Organic Electronic Materials.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  11. Article
  12. Article
  13. Nanomaterial-Based Inkjet Printing for Electrochemical Sensing.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Minqiang Wang *Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-7775-8341
Cui Ye *Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0001-7689-6825
Yiran YangAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.
Daniel MukasaDepartment of Applied Physics and Materials Science, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.
Canran WangAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.
Changhao XuAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-6817-3341
Jihong MinAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.
Samuel A SolomonAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0001-7199-6659
Jiaobing TuAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.
Guofang ShenDepartment of Hematologic Malignancy Translational Sciences, Beckman Research Institute at City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-6653-0440
Songsong TangAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-4699-6563
Tzung K HsiaiDivision of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Zhaoping LiDivision of Clinical Nutrition, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jeannine S McCuneDepartment of Hematologic Malignancy Translational Sciences, Beckman Research Institute at City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0002-0795-497X
Wei GaoAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA. weigao@caltech.edu.ORCID http://orcid.org/0000-0002-8503-4562

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Optimizing GVHD Prevention with Systems Pharmacology ModelsU01CA239373 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HORNE, DAVID A., MAGER, DONALD E · 2019 to 2023
$3.0M
Intravascular Deployment of a Wirelessly Powered Micro-PacerR01HL149808 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tzung K Hsiai · 2020 to 2026
$2.8M
Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic DiseaseR01HL155815 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GAO, WEI · 2021 to 2025
$2.0M
Cyclophosphamide Pharmacokinetics and PharmacometabolomicsR01GM129863 · NIGMS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI MCCUNE, JEANNINE S · 2018 to 2019
$672k
Cutaneous uric acid and metabolite monitoring to improve individual response to pharmaceutical and dietary treatment in patients with goutR21DK132666 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI FITZGERALD, JOHN D, GAO, WEI · 2022 to 2023
$461k
American Cancer Society (American Cancer Society, Inc.) RSG-21-181-01-CTPSNational Aeronautics and Space Administration (NASA) 80NSSC20M0167NCI NIH HHS P30 CA033572NCI NIH HHS U01 CA239373NHLBI NIH HHS R01 HL149808NHLBI NIH HHS R01 HL155815NIDDK NIH HHS R21 DK132666NIGMS NIH HHS R01 GM129863United States Department of Defense | United States Army | U.S. Army Research, Development and Engineering Command | Army Research Office (ARO) W911NF-23-1-0041United States Department of Defense | United States Navy | Office of Naval Research (ONR) N00014-21-1-2483United States Department of Defense | United States Navy | Office of Naval Research (ONR) N00014-21-1-2845U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM129863U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21DK13266U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01CA239373
6 · The paper itself

Abstract

Wearable and implantable biosensors are pioneering new frontiers in precision medicine by enabling continuous biomolecule analysis for fundamental investigation and personalized health monitoring. However, their widespread adoption remains impeded by challenges such as the limited number of detectable targets, operational instability and production scalability. Here, to address these issues, we introduce printable core-shell nanoparticles with built-in dual functionality: a molecularly imprinted polymer shell for customizable target recognition, and a nickel hexacyanoferrate core for stable electrochemical transduction. Using inkjet printing with an optimized nanoparticle ink formulation, we demonstrate the mass production of robust and flexible biosensors capable of continuously monitoring a broad spectrum of biomarkers, including amino acids, vitamins, metabolites and drugs. We demonstrate their effectiveness in wearable metabolic monitoring of vitamin C, tryptophan and creatinine in individuals with long COVID. Additionally, we validate their utility in therapeutic drug monitoring for cancer patients and in a mouse model through providing real-time analysis of immunosuppressants such as busulfan, cyclophosphamide and mycophenolic acid.

Indexed as

Biosensing TechniquesNanoparticlesProstheses and ImplantsWearable Electronic DevicesAnimalsCOVID-19Drug MonitoringHumansMiceMolecularly Imprinted PolymersSARS-CoV-2Molecularly Imprinted Polymers

Identifiers

PMID39900737
PMCPMC12129624

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.