Evidence map›Paper›PMID 39901038›Full record

ArticleCell death and differentiation2025

Protein kinase A regulates ferroptosis by controlling GPX4 m

Xiaocheng Zhao, Yanxi Sun, Juan Zou, Yanxia Wu, Minyi Huang, Huimin Kong, Guangda Liu, Holger Gerhardt, Wei Gu, Yunjiao Zhang and 2 more

Abstract read
In one paragraph

Article in Cell death and differentiation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. RNA modifications and cancer ferroptosis.Cancer cell international · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaocheng Zhao *Clinical Research Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China. zxc@mail.ustc.edu.cn.ORCID 0000-0002-4048-6813
Yanxi Sun *Clinical Research Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.ORCID 0009-0005-8556-356X
Juan ZouClinical Research Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.
Yanxia WuLaboratory of Cell Fate and Metabolic Regulation, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.
Minyi HuangClinical Research Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.
Huimin KongClinical Research Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.
Guangda LiuSchool of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China.
Holger GerhardtMax Delbrück Center for Molecular Medicine, Berlin, Germany.ORCID 0000-0002-3030-0384
Wei GuInstitute for Cancer Genetics, and Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY, 10032, USA.ORCID 0000-0002-1480-2368
Yunjiao ZhangSchool of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China. zhangyunjiao@scut.edu.cn.ORCID 0000-0002-6465-7488
Min ShangZhejiang Key Laboratory of Cardiovascular Intervention and Precision Medicine, Engineering Research Center for Cardiovascular Innovative Devices of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. minshang@zju.edu.cn.ORCID 0000-0003-4511-4290
Xingwu WangLaboratory of Cell Fate and Metabolic Regulation, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China. wxwbio@mail.ustc.edu.cn.ORCID 0000-0002-2457-8726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GPX4-dependent ferroptosis has emerged as a therapeutic strategy for cancer treatment. Here, we demonstrated that protein kinase A (PKA) participates in the regulation of ferroptosis by controlling the m

Indexed as

AlkB Homolog 5, RNA DemethylaseCyclic AMP-Dependent Protein KinasesFerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseAnimalsHEK293 CellsHumansMicePhosphorylationALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseCyclic AMP-Dependent Protein KinasesPhospholipid Hydroperoxide Glutathione Peroxidase

Identifiers

PMID39901038
PMCPMC12163066

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.