Evidence map›Paper›PMID 39901351›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy.

Andrew I Mikhail, Sean Y Ng, Donald Xhuti, Magda A Lesinski, Jennifer Chhor, Marc-Olivier Deguise, Yves De Repentigny, Joshua P Nederveen, Rashmi Kothary, Mark A Tarnopolsky and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrew I MikhailDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Sean Y NgDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Donald XhutiDepartment of Pediatrics, McMaster University Medical Center, Hamilton, Ontario, Canada.
Magda A LesinskiDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Jennifer ChhorDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Marc-Olivier DeguiseRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Yves De RepentignyRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Joshua P NederveenDepartment of Pediatrics, McMaster University Medical Center, Hamilton, Ontario, Canada.
Rashmi KotharyRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Mark A TarnopolskyDepartment of Pediatrics, McMaster University Medical Center, Hamilton, Ontario, Canada.
Vladimir LjubicicDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-4592-4093

Funding

Canadian Institutes of Health Research (CIHR)Muscular Dystrophy Canada, Canada Research Chairs programOntario Ministry of Economic Development, Job Creation and Trade (MEDJCT)
6 · The paper itself

Abstract

backgroundSpinal muscular atrophy (SMA) is a health- and life-limiting neuromuscular disorder. Although varying degrees of mitochondrial abnormalities have been documented in SMA skeletal muscle, the influence of disease progression on pathways that govern organelle turnover and dynamics are poorly understood. Thus, the purpose of this study was to investigate skeletal muscle mitochondria during SMA disease progression and determine the effects of therapeutic modalities on organelle biology.

methodsSmn

resultsSmn

conclusionsAbnormal skeletal muscle mitochondrial turnover and dynamics are associated with disease progression in Smn

Indexed as

AutophagyMitochondriaMitochondria, MuscleMuscle, SkeletalMuscular Atrophy, SpinalAnimalsDisease Models, AnimalDisease ProgressionHumansMiceautophagybiogenesisdynamicsexercisemitophagyurolithin A

Identifiers

PMID39901351
PMCPMC11790611

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.