ArticleRenal failure2025
Anxiety as a mediator between symptom distress and quality of life in peritoneal dialysis patients: insights from mediation analysis and nonlinear models.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Psychological resilience mediates the impact of anxiety and insomnia on health-related quality of life in maintenance dialysis patients.Renal failure · 2026Article
- Latent profile analysis identifying symptom clusters of fatigue, sleep disturbance, pain, and anxiety and their associations with health-related quality of life and self-efficacy in patients undergoing peritoneal dialysis: a cross-sectional study.Health and quality of life outcomes · 2026Article
- Proactive health management and psychological distress among perimenopausal women: A cross-sectional latent profile and mediation analysis.Scientific reports · 2026Article
- Contribution of family Support, illness perception, and psychological factors to fluid management behaviors in peritoneal dialysis patients.Scientific reports · 2026Article
- Illness perception mediates the association between emotional intelligence and symptom distress among patients undergoing peritoneal dialysis: a Common-Sense Model approach.Frontiers in public health · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
objectivesThis study investigates anxiety's role as a mediator between symptom burden and quality of life in patients undergoing peritoneal dialysis, emphasizing the potential for targeted interventions to enhance patient outcomes.
methodsIn a cross-sectional design, 320 peritoneal dialysis patients were recruited, with 305 providing valid responses (response rate: 95.31%). Symptom burden (occurrence and distress), anxiety levels, and quality of life were measured using validated tools. Multiple linear regression and restricted cubic spline models assessed associations, using β with a 95% confidence interval (95% CI), while mediation analysis with 1000 bootstrap samples quantified anxiety's mediating effects.
resultsParticipants reported an average of 8.2 ± 2.3 concurrent symptoms, with 'worry,', 'tiredness', and 'dry skin' being the most severe. Both symptom number (β = -0.90; 95%CI: -1.26 to -0.55) and distress (β = -1.20; 95%CI: -1.41 to -0.98) negatively correlated with quality of life. Anxiety mediated these relationships significantly, explaining 38.9% (95%CI: 18%-62%) and 33.3% (95%CI: 19%-49%) of the total effects for symptom number and distress, respectively. Restricted cubic spline models revealed an 'L-shaped' relationship between symptom burden and quality of life.
conclusionsAnxiety significantly mediates the relationship between symptom burden and quality of life in peritoneal dialysis patients. These findings underline the importance of integrating psychological interventions and routine symptom screening into patient care to enhance quality of life. Future research should explore longitudinal designs and standardized intervention strategies.
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