Evidence map›Paper›PMID 39901709›Full record

ArticleAnimal bioscience2025

Effects of a multi-strain probiotic on productive traits, antioxidant defence, caecal microbiota and short‑chain fatty acid profile, and intestinal histomorphology in rabbits.

Vincenzo Tufarelli, Caterina Losacco, Gianluca Pugliese, Alessandra Tateo, Michele Schiavitto, Fabrizio Iarussi, Vito Laudadio, Letizia Passantino

Abstract read
In one paragraph

Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Dietary probiotic supplementation withAnimal biotechnology · 2025
    Article
  8. Nano-Encapsulated Cumin Oil andVeterinary sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vincenzo TufarelliDepartment of Precision and Regenerative Medicine and Jonian Area, Section of Veterinary Science and Animal Production, University of Bari Aldo Moro, Valenzano, Bari, Italy.
Caterina LosaccoDepartment of Precision and Regenerative Medicine and Jonian Area, Section of Veterinary Science and Animal Production, University of Bari Aldo Moro, Valenzano, Bari, Italy.
Gianluca PuglieseDepartment of Precision and Regenerative Medicine and Jonian Area, Section of Veterinary Science and Animal Production, University of Bari Aldo Moro, Valenzano, Bari, Italy.
Alessandra TateoDepartment of Precision and Regenerative Medicine and Jonian Area, Section of Veterinary Science and Animal Production, University of Bari Aldo Moro, Valenzano, Bari, Italy.
Michele SchiavittoItalian Rabbit Breeders Association (ANCI-AIA), Volturara Appula, Foggia, Italy.
Fabrizio IarussiDepartment of Precision and Regenerative Medicine and Jonian Area, Section of Veterinary Science and Animal Production, University of Bari Aldo Moro, Valenzano, Bari, Italy.
Vito LaudadioDepartment of Precision and Regenerative Medicine and Jonian Area, Section of Veterinary Science and Animal Production, University of Bari Aldo Moro, Valenzano, Bari, Italy.
Letizia PassantinoDepartment of Precision and Regenerative Medicine and Jonian Area, Section of Veterinary Science and Animal Production, University of Bari Aldo Moro, Valenzano, Bari, Italy.

Funding

European UnionUniversity of Bari Aldo Moro
6 · The paper itself

Abstract

objectiveThis paper aimed to evaluate the effects of a multi-strain probiotic (MS-Prob) as natural feed additives on the productive performance, blood parameters, antioxidant defence, caecal short-chain fatty acid profile as well as the effectiveness on the intestinal morphology and on the equilibrium modification of caecal microbiota of growing rabbits.

methodsEighty-six-week-old Italian White rabbits were assigned into two dietary groups: the control group was fed without any additive, while the test group received a diet supplemented with a MS-Prob (Slab51) at a dosage of 250 mg/kg diet. The feeding trial lasted up to 12 weeks of age.

resultsRabbits MS-Prob diet had significantly higher daily and final body weight recording also the best of feed efficiency compared to control group. Rabbits in MS-Prob group showed improved slaughter weight and carcass dressing yield. No significant effect was found on meat protein, lipids and ash contents. Serum total cholesterol, low-density lipoprotein, high-density lipoprotein and triglycerides decreased significantly in rabbits fed the test-diet. In rabbits fed MS-Prob, the activity of glutathione peroxidase, glutathione S-transferase, catalase and superoxide dismutase increased significantly, whereas the level of thiobarbituric acid-reactive substance decreased significantly. Caecal pH, ammonia-N and total volatile fatty acids (VFAs) were not significantly influenced by dietary treatments. Conversely, VFAs molar proportions were statistically affected by diets, with higher acetic and butyric acid concentrations in caecum of rabbits fed MS-Prob. Feeding of MS-Prob reduced harmful bacterial growth (Escherichia coli, Bacillus spp., Clostridium spp.) while promoting beneficial bacteria (Lactobacillus spp., Bacteroides spp.). Moreover, MS-Prob positively influences rabbit gut histomorphology, showing higher villus height, villus width, and crypt depth.

conclusionThis study indicated that MS-Prob (Slab51) supplementation stimulated the performance of growing rabbits and positively affected blood serum parameters, intestinal morphology, and caecal environment and microbiota.

Indexed as

Caecal EnvironmentGut MorphologyMicrobiotaProbioticRabbit

Identifiers

PMID39901709
PMCPMC12061584

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.