Evidence map›Paper›PMID 39902764›Full record

ArticleNanomedicine (London, England)2025

A nano drug delivery system loading drugs and chlorin e6 separately to achieve photodynamic-chemo combination therapy.

Guohao Yin, Hongli Zhao, Minbo Lan

Abstract read
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Article in Nanomedicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Guohao YinShanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, People's Republic of China.
Hongli ZhaoShanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, People's Republic of China.
Minbo LanShanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, People's Republic of China.ORCID 0000-0002-4247-0006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo develop a new drug delivery system (DDS) that can load chemotherapy agents and photosensitizer chlorin e6 (Ce6) onto the pores and surfaces of mesoporous silica nanoparticle (MSN) separately.

methodsDoxorubicin (DOX) was loaded into the pores of MSNs. Then, polyethyleneimine (PEI) was used to coat the surface of MSN to protect DOX, and then manganese dioxide (MnO

resultsThe synthesized versatile nanoparticle was pH-sensitive and exhibited positive photodynamic therapy (PDT) performance. Besides, it could be observed that the nanoparticles were efficiently taken up by tumor cells through confocal laser scanning microscopy (CLSM) and flow cytometry. Additionally, in vitro experiments suggested that the nanoparticles had pleasing toxicity to various tumor cells and equally positive therapeutic effect when curcumin replaced DOX.

conclusionOur work suggests that the nanoparticles designed by our strategy have satisfactory combination therapy performance and can enable more chemotherapy drugs to be used in photodynamic-chemo combination therapy.

Indexed as

DoxorubicinNanoparticle Drug Delivery SystemNanoparticlesPhotochemotherapyPhotosensitizing AgentsPorphyrinsAntineoplastic AgentsCell Line, TumorCell SurvivalChlorophyllidesCombined Modality TherapyDrug Delivery SystemsHumansHyaluronic AcidIndolesManganese CompoundsAntineoplastic AgentsChlorophyllidesDoxorubicinHyaluronic AcidIndolesManganese Compoundsmanganese dioxideNanoparticle Drug Delivery SystemOxidesPhotosensitizing AgentsphytochlorinpolydopaminePolyethyleneiminePolymersPorphyrinsSilicon Dioxidechlorin e6curcumindoxorubicinmesoporous silica nanoparticlesPhotodynamic-chemo combination therapyreactive oxygen species

Identifiers

PMID39902764
PMCPMC11881829

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.