Evidence map›Paper›PMID 39902785›Full record

ReviewBioanalysis2025

The development and evolution of biological AMS at Livermore: a perspective.

Graham Bench

Abstract readReview
In one paragraph

Review in Bioanalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Graham BenchPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.

Funding

National User Resource for Biological Accelerator Mass SpectrometryR24GM137748 · NIGMS · LAWRENCE LIVERMORE NATIONAL SECURITY, LLC · PI BENCH, GRAHAM · 2020 to 2024
$6.5M
NIGMS NIH HHS R24 GM137748
6 · The paper itself

Abstract

Biological accelerator mass spectrometry (AMS) provides ultrasensitive carbon-14 isotopic analysis enabling a deeper understanding of human health concerns by enabling quantification of pharmacokinetics and other molecular endpoints directly in humans. It enables environmentally and human relevant studies of metabolic pathways through the use of very low concentrations of labeled metabolic substrates in cells and organisms. Here, we discuss why AMS is an important tool for the biosciences, the development and evolution of biological AMS at Livermore and discuss technical refinements that will improve the efficiency of operation for the measurement of ultra-trace levels of

Indexed as

Mass SpectrometryAnimalsCarbon IsotopesCarbon RadioisotopesHumansCarbon IsotopesCarbon RadioisotopesAccelerator Mass Spectrometry (AMS)bioAMScarbon-14DistributionHuman AdsorptionMetabolism and Elimination (ADME) studiespharmacologytoxicologyultra sensitive isotope detection

Identifiers

PMID39902785
PMCPMC11875510

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.