ArticleInternational journal of hygiene and environmental health2025
Associations of PFAS and pesticides with lung function changes from adolescence to young adulthood in the ESPINA study.
Article in International journal of hygiene and environmental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Urinary pesticide biomarker associations with depression and anxiety scores from adolescence into young adulthood in the ESPINA cohort.Journal of psychiatric research · 2026Article
- PPAR-gamma regulates PFAS-mediated proinflammatory cytokines in lung epithelial cells.Frontiers in pharmacology · 2026Article
- Fibrotic Disease of the Skin and Lung: Shared Pathways, Environmental Drivers, and Therapeutic Opportunities in a Changing Climate.International journal of molecular sciences · 2025Review
- Pesticide and Liver Biomarkers Among Ecuadorian Adolescents and Adults Living in Agricultural Settings.Toxics · 2025Article
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12 authors.
Funding
Abstract
Per- and polyfluoroalkyl substances (PFAS) and pesticides are widespread environmental contaminants linked to adverse health outcomes; yet, their impact on lung function-individually and as mixtures-remains poorly understood. This study analyzed data from 381 adolescents in a longitudinal cohort in Ecuador, measuring serum levels of three PFAS (perfluorooctanoic acid [PFOA], perfluorooctanesulfonic acid [PFOS], and perfluorononanoic acid [PFNA]) and urinary levels of three pesticides (glyphosate, 2,4-dichlorophenoxyacetic acid [2,4-D], and ethylene thiourea [ETU]). Spirometric lung function was assessed in 2016 and 2022. We evaluated associations between individual chemical levels and lung measures in log-log models estimated via ordinary least squares regression. We used quantile g-computation to assess the association of the mixture of PFAS and pesticides with lung function outcomes. After accounting for multiple hypothesis testing, and in a range of socioeconomic, geographic variables, and tobacco exposure, no statistically significant associations were observed for individual or combined exposures with lung function outcomes, after correcting for multiple hypothesis testing. Slight, non-significant increases in FEV1/FVC were noted for PFOA, glyphosate, and ETU levels between 2016 and 2022. Our findings suggest that PFAS and pesticides, either individually or in combination, may not have substantial effects on adolescent lung function in this mid-to-high-altitude agricultural population. Further research is needed to assess these relationships in larger cohorts and over longer exposure periods.
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Registered trials
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