Evidence map›Paper›PMID 39904851›Full record

Trial reportAnnals of surgical oncology2025

Intraoperative Endoluminal Pyloromyotomy Versus Stretching of the Pylorus for the Reduction of Delayed Gastric Emptying After Pylorus-Preserving Partial Pancreatoduodenectomy: A Blinded Randomized Controlled Trial (PORRIDGE Study; DRKS00013503).

Matthias C Schrempf, Matthias Anthuber, Johann Spatz, Florian Sommer, Dmytro Vlasenko, Bernd Geissler, Sebastian Wolf, Stefan Schiele, David R M Pinto, Michael Hoffmann

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthias C SchrempfDepartment of General, Visceral and Transplantation Surgery, University Hospital Augsburg, Augsburg, Germany. matthias.schrempf@uk-augsburg.de.ORCID http://orcid.org/0000-0002-2220-6427
Matthias AnthuberDepartment of General, Visceral and Transplantation Surgery, University Hospital Augsburg, Augsburg, Germany.
Johann SpatzDepartment of General and Visceral Surgery, Barmherzige Brueder Krankenhaus Munich, Munich, Germany.
Florian SommerDepartment of General, Visceral and Transplantation Surgery, University Hospital Augsburg, Augsburg, Germany.
Dmytro VlasenkoDepartment of General, Visceral and Transplantation Surgery, University Hospital Augsburg, Augsburg, Germany.
Bernd GeisslerDepartment of General, Visceral and Transplantation Surgery, University Hospital Augsburg, Augsburg, Germany.
Sebastian WolfDepartment of General, Visceral and Thoracic Surgery, Asklepios Stadtklinik Bad Tölz, Bad Tölz, Germany.
Stefan SchieleDepartment of Computational Statistics and Data Analysis, Institute of Mathematics, University of Augsburg, Augsburg, Germany.
David R M Pinto *Department of General, Visceral and Transplantation Surgery, University Hospital Augsburg, Augsburg, Germany.
Michael Hoffmann *Department of General, Visceral and Transplantation Surgery, University Hospital Augsburg, Augsburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPylorus-preserving partial pancreatoduodenectomy (ppPD) is a treatment for tumors of the pancreatic head. Delayed gastric emptying (DGE) is one of the most common complications following ppPD. In a retrospective analysis, intraoperative endoluminal pyloromyotomy (PM) was shown to be associated with a reduction in DGE rates.

objectiveThe aim of this randomized controlled trial was to investigate the effect of intraoperative endoluminal PM on DGE after ppPD.

methodsPatients undergoing ppPD were randomized intraoperatively to receive either PM or atraumatic stretching of the pylorus prior to creation of the duodenojejunostomy. The primary endpoint was the rate of DGE within 30 days after surgery.

resultsSixty-four patients were randomly assigned to the PM group and 64 patients were assigned to the control group. There were no differences between the two groups regarding baseline characteristics. The DGE rate was 59.4% (76/126). In two patients (1.6%) DGE was not assessable. The most common DGE grade was A (51/126, 40.5%), followed by B (20/126, 15.9%) and C (5/126, 4.0%). The rate of DGE was 62.5% in the PM group versus 56.3% in the control group (odds ratio 1.41, 95% confidence interval 0.69-2.90; p = 0.34). The complication rate did not differ between both groups (p = 0.79) and there were no differences in quality of life on postoperative day 30.

conclusionsIntraoperative endoluminal PM did not reduce the rate or severity of DGE after ppPD compared with atraumatic stretching of the pylorus.

Indexed as

Gastric EmptyingGastroparesisOrgan Sparing TreatmentsPancreatic NeoplasmsPancreaticoduodenectomyPostoperative ComplicationsPyloromyotomyPylorusAgedFemaleFollow-Up StudiesHumansIntraoperative CareMaleMiddle AgedPrognosisDelayed gastric emptyingPancreatic surgeryPartial pancreatoduodenectomyPostoperative complicationsPyloromyotomyRandomized controlled trial

Identifiers

PMID39904851
PMCPMC12049319

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.