Evidence map›Paper›PMID 39904887›Full record

ArticleMikrochimica acta2025

A turn-on fluorescent immunosensor for neurodegenerative disease related neurofilament light chain protein.

Qingting Song, Hailong Zhang, Jia Kong, Man Shing Wong, Hung-Wing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Ultrasensitive Detection of Neurofilament Light in Plasma Using F(Ab')Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qingting SongDepartment of Chemistry, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Hailong ZhangDepartment of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China.
Jia KongDepartment of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China.
Man Shing WongDepartment of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China. mswong@hkbu.edu.hk.
Hung-Wing LiDepartment of Chemistry, The Chinese University of Hong Kong, Hong Kong, SAR, China. hungwingli@cuhk.edu.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases (NDs) pose significant challenges to both longevity and quality of life, affecting millions worldwide and ranking as a major cause of global morbidity and disability. There is an urgent need for less invasive, cost-effective diagnostic methods that can reliably detect ND-related biomarkers in readily available biofluids such as serum. In response to this need, we have developed an ultra-sensitive assay that utilizes magnetic nanoparticles and a novel, tailor-made turn-on fluorescent probe named F-SPG. This innovative assay enables the detection of neurofilament light chain (NfL) at femtomolar concentrations, with a remarkable detection limit of 24 fM which is at least 18 times more sensitive than the conventional ELISA kits. Our assay's design eliminates the need for traditional secondary antibody in immunoassay, thereby streamlining the diagnostic process. Recoveries exceeding 95% underscore the assay's precision and reliability. It has proven effective in distinguishing Alzheimer's Disease patients from healthy individuals by quantifying serum NfL levels, showcasing its potential as a cost-effective, ultra-sensitive tool for the early screening of neurodegenerative diseases.

Indexed as

Fluorescent DyesNeurodegenerative DiseasesNeurofilament ProteinsAlzheimer DiseaseBiomarkersHumansImmunoassayLimit of DetectionMagnetite NanoparticlesBiomarkersFluorescent DyesMagnetite Nanoparticlesneurofilament protein LNeurofilament ProteinsCost-effective diagnostic toolEarly screeningImmunoassayMagnetic nanoparticlesNeurodegenerative diseasesNeurofilament light chain (NfL)

Identifiers

PMID39904887
PMCPMC11794385

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.