ArticleBMC nephrology2025
Associations between depressive and anxiety symptoms and incident kidney failure in patients with diabetic nephropathy.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Latent profile analysis identifying symptom clusters of fatigue, sleep disturbance, pain, and anxiety and their associations with health-related quality of life and self-efficacy in patients undergoing peritoneal dialysis: a cross-sectional study.Health and quality of life outcomes · 2026Article
- Motivational psychological nursing reduces anxiety and depression in patients with rheumatic and immunological diseases combined with nephropathy.World journal of psychiatry · 2025Article
- Development and validation of nursing-oriented risk prediction models for anxiety and depression in hospitalized patients with chronic kidney disease: a retrospective cross-sectional study in Southwest China.Frontiers in psychiatry · 2025Article
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Authors and funding
6 authors.
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Abstract
objectiveThis study aimed to analyze the associations between depressive and anxiety symptoms and risk of incident kidney failure in patients with biopsy-proven diabetic nephropathy (DN).
methodsThis retrospective study enrolled 241 type 2 diabetic patients with biopsy-proven DN. Huaxi Emotional-Distress Index (HEI) was used to evaluate the depression and anxiety status of patients on admission. According to the HEI score, DN patients were divided into HEI score ≤ 8 group (without depression and anxiety) and HEI score > 8 group (with depression and anxiety). The study endpoint was defined as progression to kidney failure. The cox proportional hazard analysis was performed to investigate the risk factors for progression to kidney failure in DN patients.
resultsTwenty-three patients had HEI score > 8, accounting for about 9.5% of all patients. Compared with HEI score ≤ 8 group, those with HEI score > 8 had more severe proteinuria, higher systolic blood pressure, and lower baseline eGFR and serum albumin levels. During a median follow-up of 28 months, the outcome event occurred in 89 (36.9%) of all the patients. After multivariable adjustment, HEI score > 8 (HR 1.825, 95% CI 1.050-3.172) was associated with an increased risk of progression to kidney failure.
conclusionDepressive and anxiety symptoms might be associated with an increased risk of progression to kidney failure in patients with DN, which implied psychosocial issues should be early screened, assessed and intervened to delay the progression of DN.
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