Evidence map›Paper›PMID 39905294›Full record

ArticleMolecular medicine (Cambridge, Mass.)2025

Mechanistic insights into 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targeting lipogenesis via the OLR1-Wnt/β-catenin pathway.

Jia Yan, Linglin Zhang, Qingyu Zeng, Yitao Qian, Ke Li, Xiaojing Liu, Yun Wu, Yu Yan, Haiyan Zhang, Szeman Cheung and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jia Yan *Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092,, China.
Linglin Zhang *Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092,, China.
Qingyu ZengInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092,, China.
Yitao QianDepartment of Dermatology, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China.
Ke LiDepartment of Dermatology, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China.
Xiaojing LiuInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092,, China.
Yun WuInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092,, China.
Yu YanInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092,, China.
Haiyan ZhangInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092,, China.
Szeman CheungDepartment of Dermatology, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China.
Jia LiuInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092,, China.
Ronald SrokaLaser-Forschungslabor, LIFE Center, University Hospital, Ludwig-Maximilian University, 82152, Planegg, Germany. Ronald.Sroka@med.uni-muenchen.de.
Xiuli WangInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092,, China. wangxiuli_1400023@tongji.edu.cn.
Lei ShiDepartment of Dermatology, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China. shi_lei@fudan.edu.cn.

Funding

Huadong Hospital Elite Talent JYRC2204Shanghai Shenkang Hospital Development Center's second round of the "Three Year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals" research-oriented physician innovation and transformation ability training project SHDC2022CRT017the National Natural Science Foundation of China 82073463the National Natural Science Foundation of China 82103768the National Natural Science Foundation of China 82473551the Shanghai Pujiang Program 22PJ1403400
6 · The paper itself

Abstract

Acne vulgaris, a prevalent chronic inflammatory skin disorder, is often characterized by hyperactive sebaceous glands and excessive sebum production, presenting a significant therapeutic challenge. While 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is clinically effective in treating moderate to severe acne, the molecular mechanisms underlying its therapeutic effects remain largely unexplored. In this study, we investigated the impact of ALA-PDT on lipid metabolism in an acne-like mouse model and in immortalized human sebocytes (XL-i-20), focusing on the role of the OLR1-Wnt/β-catenin pathway. We employed transcriptomic analysis, lipid staining, and gene silencing techniques to dissect the molecular interactions induced by ALA-PDT. Our findings revealed that ALA-PDT significantly reduces lipogenesis by upregulating OLR1, which in turn suppresses the SREBP1-FAS axis, thereby decreasing lipid accumulation in sebocytes. Furthermore, activation of the OLR1-Wnt/β-catenin pathway was essential for these lipogenic effects, as silencing OLR1 or activating Wnt/β-catenin signaling reversed lipogenesis inhibition. This study elucidates a novel mechanistic pathway in ALA-PDT-mediated acne treatment, highlighting OLR1 as a promising target for future therapeutic strategies.

Indexed as

Acne VulgarisAminolevulinic AcidLipogenesisPhotochemotherapyPhotosensitizing AgentsReceptors, G-Protein-CoupledWnt Signaling PathwayAnimalsbeta CateninCell LineDisease Models, AnimalHumansMiceSebaceous GlandsAminolevulinic Acidbeta CateninPhotosensitizing AgentsReceptors, G-Protein-Coupled

Identifiers

PMID39905294
PMCPMC11792739

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.