Evidence map›Paper›PMID 39906285›Full record

ArticleNAR molecular medicine2025

Combining CRISPR activation and interference capabilities using dCas9 and G-quadruplex structures.

Mohammad Lutful Kabir, Sineth G Kodikara, Mohammed Enamul Hoque, Sajad Shiekh, Janan Alfehaid, Soumitra Basu, Hamza Balci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cap-Independent Translation Regulation of VEGF Using CRISPR-dCas13d.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Mohammad Lutful KabirDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, United States.
Sineth G KodikaraDepartment of Physics, Kent State University, Kent, OH 44242, United States.
Mohammed Enamul HoqueDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, United States.
Sajad ShiekhDepartment of Physics, Kent State University, Kent, OH 44242, United States.ORCID https://orcid.org/0000-0002-8400-4679
Janan AlfehaidDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, United States.
Soumitra BasuDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, United States.
Hamza BalciDepartment of Physics, Kent State University, Kent, OH 44242, United States.ORCID https://orcid.org/0000-0002-0273-4871

Funding

Targeting Promoter G-quadruplexes with CRISPR-dCas9 for Transcription RegulationR15GM146180 · NIGMS · KENT STATE UNIVERSITY · PI BALCI, HAMZA · 2022 to 2023
$539k
NIGMS NIH HHS R15 GM146180
6 · The paper itself

Abstract

We demonstrate that both Clustered regularly interspaced short palindromic repeats (CRISPR) interference and CRISPR activation can be achieved at RNA and protein levels by targeting the vicinity of a putative G-quadruplex (GQ)-forming sequence (PQS) in the

Identifiers

PMID39906285
PMCPMC11788920

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.