Evidence mapPaperPMID 39907014Full record

ArticleCirculation2025

CD4

Taylor C Kress, Candee T Barris, Laszlo Kovacs, Beryl N Khakina, Coleton R Jordan, Thiago Bruder-Nascimento, David W Stepp, Rodger MacArthur, Vijay S Patel, Jie Chen and 3 more

Abstract read
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Pulmonary Immune Cell Landscape Altered by Exposure to HIV,International journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Role of HIV-encoded proteins in cardiovascular disease.American journal of physiology. Cell physiology · 2025
    Review
  7. Mouse Models of HIV-Associated Atherosclerosis.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Taylor C KressVascular Biology Center (T.C.K., C.T.B., L.K., B.N.K., C.R.J., T.B.-N., D.W.S., S.K., E.J.B.d.C.), University of South Alabama, Mobile.ORCID 0000-0003-2615-3788
Candee T BarrisVascular Biology Center (T.C.K., C.T.B., L.K., B.N.K., C.R.J., T.B.-N., D.W.S., S.K., E.J.B.d.C.), University of South Alabama, Mobile.ORCID 0000-0001-5313-6487
Laszlo KovacsVascular Biology Center (T.C.K., C.T.B., L.K., B.N.K., C.R.J., T.B.-N., D.W.S., S.K., E.J.B.d.C.), University of South Alabama, Mobile.ORCID 0000-0002-9886-6755
Beryl N KhakinaVascular Biology Center (T.C.K., C.T.B., L.K., B.N.K., C.R.J., T.B.-N., D.W.S., S.K., E.J.B.d.C.), University of South Alabama, Mobile.ORCID 0009-0003-0792-6498
Coleton R JordanVascular Biology Center (T.C.K., C.T.B., L.K., B.N.K., C.R.J., T.B.-N., D.W.S., S.K., E.J.B.d.C.), University of South Alabama, Mobile.ORCID 0009-0009-5438-0030
Thiago Bruder-NascimentoVascular Biology Center (T.C.K., C.T.B., L.K., B.N.K., C.R.J., T.B.-N., D.W.S., S.K., E.J.B.d.C.), University of South Alabama, Mobile.ORCID 0000-0001-5671-318X
David W SteppVascular Biology Center (T.C.K., C.T.B., L.K., B.N.K., C.R.J., T.B.-N., D.W.S., S.K., E.J.B.d.C.), University of South Alabama, Mobile.ORCID 0000-0003-0184-8321
Rodger MacArthurDepartment of Medicine (R.M., V.S.P., E.J.B.d.C.), University of South Alabama, Mobile.
Vijay S PatelDepartment of Medicine (R.M., V.S.P., E.J.B.d.C.), University of South Alabama, Mobile.ORCID 0000-0002-8402-2682
Jie ChenDepartment of Biostatistics (J.C.), University of South Alabama, Mobile.ORCID 0000-0003-2151-5276
Rafal PacholczykDepartment of Biochemistry and Molecular Biology (R.P.), Medical College of Georgia at Augusta University, Mobile.ORCID 0000-0002-9629-4829
Simone KennardVascular Biology Center (T.C.K., C.T.B., L.K., B.N.K., C.R.J., T.B.-N., D.W.S., S.K., E.J.B.d.C.), University of South Alabama, Mobile.
Eric J Belin de ChantemèleVascular Biology Center (T.C.K., C.T.B., L.K., B.N.K., C.R.J., T.B.-N., D.W.S., S.K., E.J.B.d.C.), University of South Alabama, Mobile.ORCID 0000-0002-0184-3830

Funding

Mechanism of cardiovascular disease in premenopausal womenR01HL155265 · NHLBI · AUGUSTA UNIVERSITY · PI Eric J Belin de Chantemele · 2022 to 2024
$1.6M
Leptin in HIV associated vascular diseasesR01HL147639 · NHLBI · AUGUSTA UNIVERSITY · PI Eric J Belin de Chantemele · 2022 to 2023
$997k
Novel mechanisms of HIV-associated pulmonary vascular diseaseR01HL176323 · AUGUSTA UNIVERSITY · 2025 to 2025
$761k
Mechanisms of HIV-associated HypertensionR01HL175471 · AUGUSTA UNIVERSITY · 2025 to 2025
$670k
Novel mechanisms of muscle and bone loss with HIV infection, antiretroviral therapy, and aging.R01AR082307 · AUGUSTA UNIVERSITY · 2025 to 2025
$621k
U2C/TL1 NC KUH TRIO ProgramU2CDK133491 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$488k
Origins of sex differences in the mechanisms of obesity-associated hypertensionF31HL168963 · AUGUSTA UNIVERSITY · 2025 to 2025
$43k
NHLBI NIH HHS F31 HL168963NHLBI NIH HHS R01 HL130301NHLBI NIH HHS R01 HL147639NHLBI NIH HHS R01 HL155265NHLBI NIH HHS R01 HL175471NHLBI NIH HHS R01 HL176323NIAMS NIH HHS R01 AR082307NIDDK NIH HHS U2C DK133491
6 · The paper itself

Abstract

backgroundAlthough combination antiretroviral therapy has increased life expectancy in people living with HIV, it has led to a marked increase in the prevalence of hypertension, the cause of which is unknown. Despite combination antiretroviral therapy, HIV-derived proteins remain expressed and produced by CD4

methodsHere, we tested the hypothesis that CD4

resultsWe reported that intact Tg26 mice and mice receiving BMT (Tg26→WT) or CD4

conclusionsWe provide the first evidence that CD4

Indexed as

CD4-Positive T-LymphocytesEndothelium, VascularHIV InfectionsHypertensionInterleukin-1alphaNADPH Oxidase 1AnimalsFemaleHIV-1HumansMaleMiceMice, Inbred C57BLMice, TransgenicInterleukin-1alphaNADPH Oxidase 1CD4-positive T-lymphocytesendotheliumHIVhypertensioninterleukin-1alphaoxidative stressviral proteins

Identifiers

PMID39907014
PMCPMC12011537

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.