Evidence map›Paper›PMID 39907937›Full record

ArticleGeroScience2025

Synergistic effects of plasma S100B and MRI measures of cerebrovascular disease on cognition in older adults.

Colleen Pappas, Christopher E Bauer, Valentinos Zachariou, T J Libecap, Beatriz Rodolpho, Tiffany L Sudduth, Peter T Nelson, Gregory A Jicha, Anika Ms Hartz, Xingfeng Shao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Colleen PappasDepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Christopher E BauerDepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Valentinos ZachariouDepartment of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
T J LibecapDepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Beatriz RodolphoDepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Tiffany L SudduthSanders Brown Center On Aging, University of Kentucky, Lexington, KY, 40536, USA.
Peter T NelsonSanders Brown Center On Aging, University of Kentucky, Lexington, KY, 40536, USA.
Gregory A JichaSanders Brown Center On Aging, University of Kentucky, Lexington, KY, 40536, USA.
Anika Ms HartzSanders Brown Center On Aging, University of Kentucky, Lexington, KY, 40536, USA.
Xingfeng ShaoKeck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Danny J J WangKeck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Brian T GoldDepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA. brian.gold@uky.edu.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related DementiasP01AG078116 · NIA · UNIVERSITY OF KENTUCKY · PI PETER T. NELSON · 2022 to 2026
$25.0M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI GREGORY A JICHA · 2021 to 2026
$23.5M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, VAN ELDIK, LINDA J · 2006 to 2020
$23.3M
Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationU01NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2023 to 2025
$3.9M
Blood-Brain Barrier Repair in Alzheimer’s Disease with EpilepsyR01AG075583 · NIA · UNIVERSITY OF KENTUCKY · PI Bjoern Bauer, Anika M.S. Hartz · 2022 to 2026
$3.6M
Bisphenol-Induced Blood-Brain Barrier Dysfunction in Alzheimer’s DiseaseR01NS133250 · NINDS · UNIVERSITY OF KENTUCKY · PI Anika M.S. Hartz · 2023 to 2026
$2.9M
Identifying Associations between Brain Iron, Neurocognitive Networks and Protective FactorsR01AG068055 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY · 2021 to 2025
$2.8M
Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)RF1AG084072 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JIANG, XUEJUAN, SHI, YONGGANG · 2023 to 2023
$2.5M
Contributions of Alzheimer's Pathology and Cerebrovascular Factors to Cognitive AgingR01AG055449 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY · 2017 to 2021
$2.3M
Non-invasive MRI mapping of BBB water exchange rate and permeabilityR01NS134712 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Danny JJ WANG · 2024 to 2026
$2.1M
Reduced BBB Water Exchange as a Preclinical Biomarker of Small Vessel DiseaseRF1NS122028 · NINDS · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, WANG, DANNY JJ · 2022 to 2022
$2.0M
NCATS NIH HHS UL1 TR001998NCATS NIH HHS UL1TR001998NIA NIH HHS NIA P30 AG028383NIA NIH HHS P01 AG078116NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG055449NIA NIH HHS R01 AG068055NIA NIH HHS R01 AG075583NIA NIH HHS RF1 AG084072NINDS NIH HHS R01 NS133250NINDS NIH HHS R01 NS134712NINDS NIH HHS RF1 NS122028NINDS NIH HHS U01 NS100614
6 · The paper itself

Abstract

There is growing interest in studying vascular contributions to cognitive impairment and dementia (VCID) and developing biomarkers to identify at-risk individuals. A combination of biofluid and neuroimaging markers may better profile early stage VCID than individual measures. Here, we tested this possibility focusing on plasma levels of S100 calcium-binding protein B (S100B), which has been linked with blood-brain-barrier (BBB) integrity, and neuroimaging measures assessing BBB function (water exchange rate across the BBB (k

Indexed as

Cerebrovascular DisordersCognitionCognitive DysfunctionMagnetic Resonance ImagingS100 Calcium Binding Protein beta SubunitAgedAged, 80 and overBiomarkersBlood-Brain BarrierFemaleHumansMaleBiomarkersS100B protein, humanS100 Calcium Binding Protein beta SubunitBlood–brain barrierDiffusionMemoryS100BVascular contributions to cognitive impairment and dementiaWhite matter hyperintensities

Identifiers

PMID39907937
PMCPMC12181517

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.