Evidence map›Paper›PMID 39908005›Full record

ArticleAmerican journal of physiology. Renal physiology2025

The impact of maternal obesity on polycystic kidney disease progression in a mouse model.

Sarah J Miller, Kaitlyn Hill, Isabella Darby, Fariha Nusrat, Jacob E Friedman, Michael C Rudolph, Kurt A Zimmerman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah J MillerDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0003-4888-5306
Kaitlyn HillDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0002-7805-5197
Isabella DarbyDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Fariha NusratDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0002-8624-721X
Jacob E FriedmanDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Michael C RudolphDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0002-6147-212X
Kurt A ZimmermanDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0003-1798-8046

Funding

Targeting kidney resident macrophage niche filling to slow cystic kidney diseaseR01DK129255 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Kurt A Zimmerman · 2022 to 2026
$1.6M
Investigating CD4 T regulatory cells during rapid cystogenesisK01DK119375 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZIMMERMAN, KURT A · 2020 to 2023
$608k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K01DK119375HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK129255-01A1NIDDK NIH HHS K01 DK119375NIDDK NIH HHS L30 DK137350NIDDK NIH HHS R01 DK129255OU Health | Harold Hamm Diabetes Center, OU Health (HHDC)PKD Foundation (PKDF) 1065555
6 · The paper itself

Abstract

Due to the growing obesity epidemic in the United States, it is now estimated that approximately one third of all children are born to obese moms. These data, coupled with data indicating that obesity is associated with accelerated cyst growth in patients with autosomal dominant polycystic kidney disease (ADPKD), led us to hypothesize that maternal obesity may influence the rate of disease progression in offspring. To test this hypothesis, we induced maternal obesity by high-fat diet (HFD) feeding in the orthologous

Indexed as

KidneyMaternal Nutritional Physiological PhenomenaObesityPolycystic Kidney, Autosomal DominantPolycystic Kidney DiseasesPregnancy in ObesityPrenatal Exposure Delayed EffectsAnimalsDiet, High-FatDisease Models, AnimalDisease ProgressionFemaleMaleMiceMice, Inbred C57BLPregnancyTRPP Cation Channelshigh-fat dietmacrophagesmaternal obesitypolycystic kidney disease

Identifiers

PMID39908005
PMCPMC12184622

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.