Evidence map›Paper›PMID 39908134›Full record

Trial reportTranslational vision science & technology2025

Structure-Function Relationships in Geographic Atrophy Based on Mesopic Microperimetry, Fundus Autofluorescence, and Optical Coherence Tomography.

Souvick Mukherjee, Thilaka Arunachalam, Cameron Duic, Maria Abraham, Christine Orndahl, Supriya Menezes, Elvira Agrón, Maximilian Pfau, Tharindu de Silva, Clare Bailey and 7 more

Registry-linked trialAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02564978 (Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02564978 phase2completednot on this map

Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration

TypeinterventionalSponsorNational Eye Institute (NEI)Ran2016 to 2023Enrolled37ConditionsAge-Related Macular DegenerationArmsMinocycline
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Visual Function Assessment in Geographic Atrophy: A Review.Clinical & experimental ophthalmology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Geographic atrophy: Understanding the relationship between structure and function.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Souvick MukherjeeNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Thilaka ArunachalamNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Cameron DuicNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Maria AbrahamThe Emmes Company, LLC, Rockville, MD, USA.
Christine OrndahlThe Emmes Company, LLC, Rockville, MD, USA.
Supriya MenezesThe Emmes Company, LLC, Rockville, MD, USA.
Elvira AgrónNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Maximilian PfauInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Tharindu de SilvaNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Clare BaileyBristol Eye Hospital, Bristol, UK.
Alisa T ThavikulwatNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Sunil BellurNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
SriniVas R SaddaDoheny Eye Institute, Pasadena, CA, USA.
Emily Y ChewNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Brett G JeffreyNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Wai T WongTiresias Biopharma Consulting LLC, Half Moon Bay, CA, USA.
Tiarnan D L KeenanNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To examine relationships between retinal structure and visual function in geographic atrophy (GA) by analyzing spatial agreement between absolute scotomas and macular structure, focusing on (1) choroidal hypertransmission, a key feature of complete retinal pigment epithelium and outer retinal atrophy (cRORA), and (2) fundus autofluorescence (FAF)-defined GA. Methods: Mesopic microperimetry (using a novel T-shaped pattern) and multimodal imaging were recorded longitudinally in a phase II GA trial. Horizontal and vertical optical coherence tomography (OCT) line scans (corresponding to the T axes) were graded for choroidal hypertransmission; FAF images were graded for GA. Spatial concordance between zones of absolute scotoma and atrophy was quantified by the Dice similarity coefficient (DSC). Results: The analysis population comprised 24 participants (mean follow-up 26.8 months). For concordance between absolute scotoma and choroidal hypertransmission, estimated mean DSC was 0.70 (95% confidence interval [CI], 0.64-0.77). This was significantly higher than for FAF-defined GA (0.67; 95% CI, 0.61-0.74; estimated mean difference = 0.03, 95% CI, 0.02-0.05, P < 0.001). Mean OCT choroidal reflectivity was strongly associated with likelihood and severity of scotoma. Conclusions: Spatial concordance between absolute scotomas and GA structural features is moderately high and slightly higher for choroidal hypertransmission than FAF-defined GA. This supports choroidal hypertransmission, a key cRORA feature, as an outcome measure in interventional trials. OCT provides more information to explain visual function than FAF alone. However, given some discordance for both structural features, performing microperimetry alongside imaging remains important. Translational Relevance: These findings provide insights into the complex relationship between retinal structure and visual function and contribute to a nuanced understanding of outcome measures.

Indexed as

Geographic AtrophyMesopic VisionTomography, Optical CoherenceVisual FieldsVisual Field TestsAgedFemaleFluorescein AngiographyFundus OculiHumansMaleMiddle AgedOptical ImagingRetinal Pigment EpitheliumScotomaVisual Acuity

Identifiers

PMID39908134
PMCPMC11806430

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.