Evidence map›Paper›PMID 39908477›Full record

ArticleBlood advances2025

Targeting RNA modification and mitochondrial metabolism cross talk in leukemic stem cells with CDK7 inhibitor TGN-1062.

Hyunjun Kang, Lianjun Zhang, Mohan R Kaadige, Melissa Valerio, Dinh Hoa Hoang, Trason Thode, Alexis Weston, Khyatiben Pathak, Lokesh Nigam, Nathanial P Hansen and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Hyunjun KangDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.
Lianjun ZhangDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.ORCID 0000-0002-5285-0088
Mohan R KaadigeApplied Cancer Research and Drug Discovery, Translational Genomics Research Institute, Phoenix, AZ.ORCID 0000-0003-3813-9107
Melissa ValerioDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.
Dinh Hoa HoangDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.
Trason ThodeApplied Cancer Research and Drug Discovery, Translational Genomics Research Institute, Phoenix, AZ.ORCID 0000-0002-4307-1234
Alexis WestonApplied Cancer Research and Drug Discovery, Translational Genomics Research Institute, Phoenix, AZ.
Khyatiben PathakEarly Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, AZ.
Lokesh NigamEarly Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, AZ.ORCID 0000-0003-2350-9910
Nathanial P HansenEarly Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, AZ.
Brooke LovellEarly Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, AZ.ORCID 0009-0008-1023-2186
Yuriy ShostakBeckman Research Institute and City of Hope National Medical Center, Duarte, CA.ORCID 0000-0003-2891-7905
Wei LiDepartment of Systems Biology, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.
Lucy GhodaDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.
Zhuo LiBeckman Research Institute and City of Hope National Medical Center, Duarte, CA.
Bin ZhangDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.
Jianjun ChenDepartment of Systems Biology, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.ORCID 0000-0003-3749-2902
Patrick PirrotteEarly Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, AZ.ORCID 0000-0003-1360-6039
Ya-Huei KuoDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.ORCID 0000-0003-2595-0419
Sunil SharmaApplied Cancer Research and Drug Discovery, Translational Genomics Research Institute, Phoenix, AZ.
Guido MarcucciDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.
Le Xuan Truong NguyenDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA.

Funding

Targeting FTO to treat acute myeloid leukemiaR01CA243386 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Jianjun Chen · 2021 to 2024
$2.2M
The role and mechanism of METTL3/METTL14-mediated RNA modification in the pathogenesis and drug-resistance of AMLR01CA236399 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Jianjun Chen · 2022 to 2023
$902k
TET2-mediated epitranscriptomic regulation in leukemia microenvironmentR01CA280389 · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2025 to 2025
$685k
The role and therapeutic potential of IGF2BP2 in MLL-rearranged leukemiaR01CA271497 · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2025 to 2025
$574k
NCI NIH HHS R01 CA214965NCI NIH HHS R01 CA236399NCI NIH HHS R01 CA243386NCI NIH HHS R01 CA271497NCI NIH HHS R01 CA280389
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39908477
PMCPMC12008692

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.