Evidence map›Paper›PMID 39909558›Full record

ArticleLife science alliance2025

Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos.

Tobias Beckröge, Bettina Jux, Hannah Seifert, Hannah Theobald, Elena De Domenico, Stefan Paulusch, Marc Beyer, Andreas Schlitzer, Elvira Mass, Waldemar Kolanus

Abstract read
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tobias BeckrögeMolecular Immunology and Cell Biology, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Bettina JuxMolecular Immunology and Cell Biology, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Hannah SeifertMolecular Immunology and Cell Biology, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Hannah TheobaldQuantitative Systems Biology, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Elena De DomenicoGenomics and Immunoregulation, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.ORCID 0000-0003-0336-8284
Stefan PauluschSystems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany.
Marc BeyerSystems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany.
Andreas SchlitzerQuantitative Systems Biology, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Elvira MassDevelopmental Biology of the Immune System, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Waldemar KolanusMolecular Immunology and Cell Biology, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany wkolanus@uni-bonn.de.ORCID 0000-0003-1325-9444

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transition of an embryo from gastrulation to organogenesis requires precisely coordinated changes in gene expression, but the underlying mechanisms remain unclear. The RNA-binding protein Trim71 is essential for development and serves as a potent regulator of post-transcriptional gene expression. Here, we show that global deficiency of

Indexed as

ErythropoiesisTripartite Motif ProteinsUbiquitin-Protein LigasesAnimalsEmbryo, MammalianEmbryonic DevelopmentEndothelial CellsFemaleGastrulationGene Expression Regulation, DevelopmentalMesodermMiceMice, KnockoutOrganogenesisT-Box Domain ProteinsTranscription FactorsER71 protein, mouseT-Box Domain ProteinsTranscription FactorsTripartite Motif ProteinsUbiquitin-Protein Ligases

Identifiers

PMID39909558
PMCPMC11799773

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.