Evidence map›Paper›PMID 39910151›Full record

ArticleScientific reports2025

Vasorelaxant effects and its mechanisms of the rhizome of Acorus gramineus on isolated rat thoracic aorta.

Jueon Lee, Sujin Shin, Junkyu Park, Ho-Young Choi, Kyungjin Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jueon Lee *Department of Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447, Korea.
Sujin Shin *Department of Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447, Korea.
Junkyu ParkDepartment of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447, Korea.
Ho-Young ChoiDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Korea.
Kyungjin LeeDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Korea. niceday@khu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In conventional medicine, the rhizome of Acorus gramineus Solander (AGR) is used to treat cardiovascular and cerebrovascular diseases. Decoctions containing AGR exert vasorelaxant effects. Therefore, this research aimed to delve deeper into the vasorelaxant effects and underlying mechanisms of AGR and its constituents (α-asarone and β-asarone). We assessed the vasorelaxant effect of a 50% ethanol extract of AGR (AGRE) using aortic rings from Sprague-Dawley rats pre-constricted with phenylephrine (PE) and potassium chloride (KCl). The findings suggested that the mechanism of this effect was independent of endothelial cells and was associated with vascular smooth muscle cells (VSMC). Since vasodilatory mechanisms associated with VSMC are predominantly influenced by K

Indexed as

AcorusAorta, ThoracicPlant ExtractsRhizomeVasodilationVasodilator AgentsAnimalsMaleMuscle, Smooth, VascularPhenylephrinePotassium ChlorideRatsRats, Sprague-DawleyPhenylephrinePlant ExtractsPotassium ChlorideVasodilator AgentsAcorus gramineusAsaroneCation channelsVasorelaxant

Identifiers

PMID39910151
PMCPMC11799538

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.