Evidence map›Paper›PMID 39910190›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Effect of bilirubin on visuocortical development in preterm infants.

William V Good, Ronald J Wong, Anthony M Norcia, Chuan Hou, Jillian Cellucci, Margaret Q McGovern, Audrey Wong-Kee-You, Gabriela Acevedo Munares, Delene Richburg, Cam Loveridge-Easther and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

William V GoodThe Smith-Kettlewell Eye Research Institute, San Francisco, CA, USA. Good@ski.org.ORCID http://orcid.org/0000-0001-7968-0114
Ronald J WongDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-1205-6936
Anthony M NorciaDepartment of Psychology, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA.
Chuan HouThe Smith-Kettlewell Eye Research Institute, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9573-416X
Jillian CellucciThe Smith-Kettlewell Eye Research Institute, San Francisco, CA, USA.
Margaret Q McGovernThe Smith-Kettlewell Eye Research Institute, San Francisco, CA, USA.
Audrey Wong-Kee-YouThe Smith-Kettlewell Eye Research Institute, San Francisco, CA, USA.
Gabriela Acevedo MunaresThe Smith-Kettlewell Eye Research Institute, San Francisco, CA, USA.
Delene RichburgCalifornia Pacific Medical Center, Department of Pediatrics, San Francisco, CA, USA.
Cam Loveridge-EastherCalifornia Pacific Medical Center, Department of Pediatrics, San Francisco, CA, USA.
Jane S LeeCalifornia Pacific Medical Center, Department of Pediatrics, San Francisco, CA, USA.
Lilia DeJesusCalifornia Pacific Medical Center, Department of Pediatrics, San Francisco, CA, USA.
Terri SlagleCalifornia Pacific Medical Center, Department of Pediatrics, San Francisco, CA, USA.
David K StevensonDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-7127-0281
Vinod K BhutaniDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-0770-6543

Funding

Effects of Hyperbilirubinemia on Visuocortical Functioning in High-Risk InfantsR01EY030537 · NEI · SMITH-KETTLEWELL EYE RESEARCH INSTITUTE · PI WILLIAM V GOOD · 2019 to 2026
$3.1M
The Effects of Prematurity on Visual DevelopmentR01EY015228 · NEI · SMITH-KETTLEWELL EYE RESEARCH INSTITUTE · PI GOOD, WILLIAM V · 2005 to 2008
$1.6M
NEI NIH HHS R01 EY015228NEI NIH HHS R01 EY030537U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EY030537
6 · The paper itself

Abstract

objectiveTo determine if visuocortical development in premature infants with high bilirubin levels is more adversely affected than that in full-term infants. STUDY

design57 preterm infants were managed using institutional guidelines for hyperbilirubinemia. At 12-months corrected age, Vernier acuity, contrast sensitivity, and grating acuity measured using the sweep visual evoked potential (sVEP) were correlated to total serum/plasma bilirubin (TSB) levels in the first week of life.

resultAs TSB levels increased, Vernier acuity worsened in infants <34 weeks' gestation compared with those >34 to <37 weeks' gestation (p < 0.001). Contrast sensitivity varied as a function of TSB levels (Spearman correlation 0.63, p < 0.001). Grating acuity was unaffected.

conclusionVernier acuity in preterm infants <34 weeks' gestation is more vulnerable to the effects of bilirubin, suggesting that the extrastriate visual cortex is primarily affected by bilirubin. Therefore, guidelines for management of hyperbilirubinemia in preterm infants (<34 weeks' gestation) should be revised.

Indexed as

BilirubinHyperbilirubinemia, NeonatalInfant, PrematureVisual CortexContrast SensitivityEvoked Potentials, VisualFemaleGestational AgeHumansInfantInfant, NewbornMaleVisual AcuityBilirubin

Identifiers

PMID39910190
PMCPMC12431845

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.