ArticleNature2025
Engineering a genomically recoded organism with one stop codon.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Automated prototyping of genetic codes.Nature · 2026Article
- Probing the limits of genetic recoding using multi-omics-guided evolution.Nature communications · 2026Article
- AI-empowered human microbiome research.Gut · 2026Review
- Advances in biocontainment strategies of engineered microbes for use in humans.Current opinion in microbiology · 2026Review
- Genetic Incorporation of Diverse Noncanonical Amino Acids for Histidine Substitution.Journal of the American Chemical Society · 2026Article
- mGem: Applying microbiome therapeutic learnings to next-generation agricultural bioproducts.mBio · 2026Review
- Natural Selection Drives AT-Biased Codon Usage in Mitochondrial Genomes of Early-DivergingJournal of fungi (Basel, Switzerland) · 2026Article
- Engineering genetic elements for microbial protein expression systems: Advances, challenges, applications, and prospects.Synthetic and systems biotechnology · 2026Review
- Chemical biology approaches to study and target circadian clocks and their components.FEBS letters · 2026Review
- Synthetic rewriting technologies in mammalian cells.Nature communications · 2026Review
- Article
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- ENSURE: the encyclopedia of suppressor tRNA with an AI assistant.Nucleic acids research · 2026Article
- Genetic code expansion for single noncanonical amino acid incorporation into SARS-CoV-2 Omicron spike on amber-free lentiviral particles.Methods in enzymology · 2026Article
- A Robust Bioprocess for the Global Incorporation of Noncanonical Amino Acids in Auxotrophic Hosts Produces Labeled Proteins at the Gram Scale.Chembiochem : a European journal of chemical biology · 2026Article
- Bioorthogonal click-chemistry labeling and visualization of dual noncanonical amino acid-incorporated HIV-1 Env on intact virions.Methods in enzymology · 2026Article
- De novo design of light-responsive protein-protein interactions enables reversible formation of protein assemblies.Nature chemistry · 2025Article
- In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins.Chembiochem : a European journal of chemical biology · 2025Review
- Article
- Engineered orthogonal translation systems from metagenomic libraries expand the genetic code.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Michael W GromeDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Michael T A Nguyen *Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Daniel W Moonan *Systems Biology Institute, Yale University, West Haven, CT, USA.
Kyle Mohler *Systems Biology Institute, Yale University, West Haven, CT, USA.ORCID 0000-0003-3072-7756
Kebron Gurara *Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.ORCID 0000-0003-1546-3932
Shenqi WangDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Colin HemezDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Benjamin J StentonDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.ORCID 0000-0001-5852-2803
Yunteng CaoDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.ORCID 0000-0002-6425-7628
Felix RadfordDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Maya KornajDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Jaymin PatelDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Maisha PromeDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Svetlana RogulinaSystems Biology Institute, Yale University, West Haven, CT, USA.
David SozanskiDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Jesse TordoffDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Jesse RinehartSystems Biology Institute, Yale University, West Haven, CT, USA. jesse.rinehart@yale.edu.ORCID 0000-0003-4839-4005
Farren J IsaacsDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA. farren.isaacs@yale.edu.ORCID 0000-0001-8615-8236
Funding
Engineering a recoded organism to discover PTM-mediated protein bindersR01GM140481 · NIGMS · YALE UNIVERSITY · PI Farren J. Isaacs · 2020 to 2026
$3.3MRevealing substrates and phosphoproteome level function of human STE20 kinasesR01GM117230 · NIGMS · YALE UNIVERSITY · PI ISAACS, FARREN J., RINEHART, JESSE · 2015 to 2024
$3.2MPredoctoral Training Program in GeneticsT32GM148332 · NIGMS · YALE UNIVERSITY · PI John R Carlson, Mandar Deepak Muzumdar · 2023 to 2026
$3.0MProgrammable Keratinous Bio-adhesives for Recalcitrant Wound RecoveryF32GM142204 · NIGMS · YALE UNIVERSITY · PI GROME, MICHAEL WILLIAM · 2021 to 2022
$136kNIGMS NIH HHS F32 GM142204NIGMS NIH HHS R01 GM117230NIGMS NIH HHS R01 GM140481NIGMS NIH HHS T32 GM148332
Abstract
The genetic code is conserved across all domains of life, yet exceptions have revealed variations in codon assignments and associated translation factors
Indexed as
Codon, TerminatorEscherichia coliGenetic CodeGenetic EngineeringGenome, BacterialEscherichia coli ProteinsGenomicsPeptide Termination FactorsProtein BiosynthesisCodon, TerminatorEscherichia coli ProteinsPeptide Termination Factors
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.