ArticleEuropean radiology experimental2025
A minimally invasive animal model of atherosclerosis and neointimal hyperplasia for translational research.
Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Towards Neoatherosclerosis: A Porcine Model for Enhanced Device Testing.Journal of cardiovascular translational research · 2026Article
- Bioinformatics Approach to Investigating the Immuno-Inflammatory Mechanisms of Periodontitis in the Progression of Atherosclerosis.Current issues in molecular biology · 2025Article
- Experimental atherosclerosis models in small animals (Review).Medicine internationalReview
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Authors and funding
12 authors.
Funding
Abstract
backgroundA variety of animal models has been developed for research on atherosclerosis and neointimal hyperplasia. While small animal models contain limits for translational research, we aimed to develop an atherosclerosis model with lumen-narrowing plaques to foster basic research in vascular biology, the development of new angioplasty devices, and vessel wall imaging approaches.
methodsEndothelial denudation was performed via a minimally invasive approach through the auricular artery, followed by stent-retriever mediated endothelial injury in New Zealand White rabbits (n = 10). Along with a high-fat diet, the rabbits developed lumen-narrowing atherosclerosis and neointimal hyperplasia of the iliac arteries within a 6-week period after mechanical injury. The stent-retriever method was compared with a conventional rabbit model (n = 10) using balloon denudation via surgical access, and both models were analyzed with a particular focus on animal welfare. Fisher's exact, Mann-Whitney U, and unpaired t-tests were used.
resultsThe average time for the entire procedure was 62 min for the balloon group and 31 min for the stent-retriever group (p < 0.001). The stent-retriever model resulted in less periprocedural morbidity (including expenditure, intubation time, anesthetics, and end-tidal CO
conclusionWe developed a minimally invasive model of iliac atherosclerosis with high reproducibility and improved animal welfare for translational research. RELEVANCE STATEMENT: This advanced rabbit model could allow for translational research in atherosclerosis, including pharmacological investigations as well as research on interventional angioplasty procedures. KEY POINTS: Rabbit models show similar lipid metabolism as humans. Stent-retriever mediated endothelial denudation causes neointimal hyperplasia and lumen narrowing. This minimal invasive model allows for clinical translation, including pharmacological investigations and vessel wall imaging.
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