ArticleCardiovascular diabetology2025
The association of triglyceride-glucose and triglyceride-glucose related indices with the risk of heart disease in a national.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The Triglyceride-Glucose Index Combined With Obesity Indices and Lower Extremity Artery Disease in Type 2 Diabetes: A Sex-Stratified Analysis.Endocrinology, diabetes & metabolism · 2026Article
- Association of a new TyG indicator, TyHGB, with cardiovascular disease incidence among the elderly: evidence from a prospective cohort study.BMC geriatrics · 2026Article
- Article
- L-shaped association of skeletal muscle mass with all-cause mortality among US adults: a population-based cohort study.Archives of public health = Archives belges de sante publique · 2026Article
- Association of the triglyceride glucose-body roundness index with stroke risk in middle-aged and elderly Chinese adults without diabetes: a prospective cohort study.Cardiovascular diagnosis and therapy · 2026Article
- Association between cumulative TyG/AIP-derived indices and terminal survival time in older patients with circulatory system diseases.BMC geriatrics · 2026Article
- Association between estimated glucose disposal rate and heart disease events in adults with overweight or obesity: a prospective cohort study.Journal of translational medicine · 2026Article
- Combined lesion-specific pericoronary adipose tissue attenuation and triglyceride-glucose body mass index for improved risk stratification of major adverse cardiovascular events in patients with stable angina pectoris.Quantitative imaging in medicine and surgery · 2026Article
- Modified cardiometabolic index and the risk of new-onset chronic diseases: a nationwide prospective cohort study.Diabetology & metabolic syndrome · 2026Article
- The relationship between IGF-1 and cardiovascular diseases and the potential mediating role of TyG-related index: evidence from a cohort study.BMC cardiovascular disorders · 2026Article
- Association Between CBC-Derived Inflammatory Indicators and 28-Day Mortality in Patients With Coronary Heart Disease and Diabetes Mellitus: A Cohort Study From the MIMIC-IV Database.Mediators of inflammation · 2026Article
- Stress hyperglycemia ratio and long-term prognosis in patients with acute myocardial infarction undergoing percutaneous coronary intervention: evidence for an J-shaped association.Journal of geriatric cardiology : JGC · 2025Article
- Associations between asprosin, insulin resistance, and oxidative stress in adults with obesity.Scientific reports · 2025Article
- Associations of longitudinal trajectories of triglyceride-glucose index combined with classical and novel obesity indices and cardiovascular disease: evidence from a nationwide prospective cohort study in China.Cardiovascular diabetology · 2025Article
- Association between the psychological frailty index and stroke: a cohort study from CHARLS.Scientific reports · 2025Article
- Association of C reactive protein triglyceride glucose index with mortality in coronary heart disease and type 2 diabetes from NHANES data.Scientific reports · 2025Article
- Triglyceride-Glucose-Based Anthropometric Indices for Predicting Incident Cardiovascular Disease: Relative Fat Mass (RFM) as a Robust Indicator.Nutrients · 2025Article
- Association between insulin resistance and multiple chronic diseases: a cross-sectional study from CHARLS.Journal of health, population, and nutrition · 2025Article
- Correction: The association of triglyceride-glucose and triglyceride-glucose related indices with the risk of heart disease in a national cohort study.Cardiovascular diabetology · 2025Article
- Triglyceride-glucose-body mass index predicts early-onset acute kidney injury in critically ill patients: a retrospective analysis using the MIMIC-IV database.Frontiers in nutrition · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between triglyceride-glucose (TyG), triglyceride-glucose related indices and heart disease remains a topic of debate in the current literature. Existing evidence in Chinese people and in diabetes or non-diabetes patients regarding this association is limited, highlighting the need for further investigation.
methodsA cohort study was conducted involving 7945 participants enrolled in the China Health and Retirement Longitudinal Study (CHARLS). The incidence of heart disease was collected by following up 9 years. TyG, TyG with body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) were collected at baseline. Multivariate Cox proportional hazards models, restricted cubic spline (RCS), Kaplan-Meier (KM) curves, subgroup analysis and sensitivity analysis were used to analyze the associations between TyG, TyG related indices and the risk of heart disease in national participants and in type 2 diabetes (T2D) or non-T2D patients respectively.
resultsDuring a 9-year follow-up, 1477 participants (18.6%) developed heart disease. Our analysis found a significant positive association between TyG-BMI, TyG-WC, and TyG-WHtR with heart disease risk in all participants. The adjusted hazard ratios (HR) for the highest quartile compared to the lowest were: TyG-BMI 1.73 (95% CI: 1.47-2.03), TyG-WC 1.46 (95% CI: 1.24-1.71), and TyG-WHtR 1.31 (95% CI: 1.11-1.54). However, TyG alone was not significantly associated with heart disease in all participants. In non-diabetic patients, the associations were consistent: TyG-BMI 1.75 (95% CI: 1.47-2.08), TyG-WC 1.47 (95% CI: 1.24-1.75), and TyG-WHtR 1.34 (95% CI: 1.13-1.60). However, in diabetes patients, no significant associations were found between TyG, TyG-WC, TyG-WHtR and heart disease risk except for the highest quartile of TyG-BMI (HR: 1.86, 95% CI: 1.02-3.40).
conclusionsIn the national population study, higher TyG-BMI, TyG-WC, and TyG-WHtR indices were significantly associated with an increased risk of heart disease, with TyG-BMI and TyG-WC showing stronger correlations. While this association was evident in non-T2D patients, only TyG-BMI was associated with heart disease incidence in T2D patients, underscoring the necessity for further investigation.
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